Christopher Coe, PhD – Slide of the Week

Birth weight (BW) at delivery is an important developmental milestone indicative of prenatal conditions and portends of the postnatal growth trajectory that will occur during infancy and childhood. Previous research has documented that there are also many physiological and health consequences of being born either small-for-gestational age (SGA) or large-for-gestational age (LGA).

Bradley T Christian, PhD – Slide of the Week

Adults with Down syndrome (DS) are predisposed to Alzheimer’s disease (AD) and a characterization of glucose metabolism change throughout AD progression has yet to be performed in this population. Using FDG PET, regional glucose metabolism was evaluated across groups of cognitively stable DS (CS-DS), DS with mild cognitive impairment or Alzheimer’s disease (MCI-DS/AD), and healthy non-DS sibling controls.

New NIH-funded initiative will examine Alzheimer’s disease in people with Down syndrome

A team of researchers at the University of Wisconsin–Madison is part of a new multi-institution effort to better understand Alzheimer’s disease in adults with Down syndrome. Adults with Down syndrome are at high risk for …

Qiang Chang, PhD – Slide of the Week

Rett syndrome (RTT) is a severe X chromosome-linked debilitating neurodevelopmental disorder caused by mutations in the MECP2 gene affects 1 in 10,000-15,000 girls with no effective treatment. Our lab has been using RTT induced pluripotent stem cells (iPSC) and neurons and astrocytes differentiated from iPSC as a platform to understand RTT disease mechanisms and develop treatment.

Sriram Boothalingam, PhD – Slide of the Week

This study describes a time series-based method of middle ear muscle reflex (MEMR) detection using bilateral clicks, with implications for otoacoustic emission (OAE)-based medial olivocochlear reflex (MOCR) assays. Although current click-based methods can detect changes in the OAE evoking stimulus to monitor the MEMR, these methods do not discriminate between true MEMR-mediated vs. artifactual changes in the stimulus.

The sound beneath the waves

If you’ve ever seen a graphical representation of a sound, you are probably familiar with what it looks like: hundreds of steep, tightly packed peaks and valleys, all of different heights, moving above and below a common line of symmetry that cuts horizontally through the middle. “When a sound travels through the air, it basically sets the molecules around us in motion, using sound pressure to create sort of a wave,” says Waisman researcher Michaela Warnecke, PhD.