The electrical properties of a neuron paint a picture of its development and function. A new user-friendly and accessible tool developed at the Waisman Center allows scientists to analyze the electrical activity of individual neurons – rather than clusters – using a process known as spike sorting. The free tool is available online for other researchers to access.
Stem Cells
What research has revealed about Down syndrome’s influence on brain development
A new review paper published in Nature Reviews Neuroscience from Bhattacharyya, associate professor of cell and regenerative biology, pulls together what is currently known about DS’s impact on brain development.
UW-Madison’s Cool Science Image Contest: Waisman winners
Matt Zammit, PhD, Waisman scientist in the Brain Imaging Core, and affiliate investigator Erik Dent, PhD, are both winners of UW-Madison’s Cool Science Image Contest.
Renowned Waisman investigator Su-Chun Zhang retires
After more than two decades at the Waisman Center, University of Wisconsin and several first-in-the-world stem cell scientific breakthroughs, Su-Chun Zhang, MD, PhD, professor of neuroscience and neurology, is retiring. He came to the Waisman …
Organoids are becoming more popular in research, consistency in their use is needed for more accurate results
To the naked eye, they look like tiny blobs free floating in a pink liquid. Under a light microscope, they look similar. But organoids, a 3-D mini version of an organ grown in a lab, may contain invaluable information about how the human brain develops.
Earliest effects of chromosome 21 triplication in brain development discovered
It is well established that brain development looks different for individuals with Down syndrome, but how early do these differences appear?
UW-Madison researchers first to 3D-print functional human brain tissue
A team of University of Wisconsin–Madison scientists has developed the first 3D-printed brain tissue that can grow and function like typical brain tissue.
Researcher clinicians help bridge the gap between scientific discovery and medical care – Part 2
There is no one “typical” type of researcher clinician. There are differences in training, percentage of focus on research vs clinic, and type of research done. Many also carry teaching and administrative responsibilities on top of their already demanding positions.
Scientists produce human norepinephrine neurons from stem cells, with significant implications for researching diseases like Alzheimer’s and Parkinson’s
Researchers a have identified a protein key to the development of a type of brain cell believed to play a role in disorders like Alzheimer’s and Parkinson’s diseases and used the discovery to grow the neurons from stem cells for the first time.
UW effort to map Down syndrome brain raises prospect of treatment for disorder
In a lab near UW Hospital, Megan Jandy grows stem cells from people with Down syndrome — 10 batches of cells, most in three-dimensional clusters, each batch featuring one group with the extra chromosome that causes the disorder and one group without it.