Down syndrome (DS, trisomy 21) is characterized by intellectual impairment at birth and Alzheimer’s disease (AD) pathology in middle age. As individuals with DS age, their cognitive functions decline as they develop AD pathology.
Pluripotent stem cell
Induced neural stem cells: Not quite ready for prime time
Intriguingly, the new study suggests the presence or absence of the genes used to reprogram skin cells to become the blank slate pluripotent cells makes no difference in terms of their capacity to differentiate.