University of Wisconsin–Madison

Tag: neurodegeneration

Earliest signs of neurodegeneration in Down syndrome detected shortly after birth, new Waisman study shows

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Signs of neurodegeneration in individuals with Down syndrome may start as early as birth, a critical stage of brain development, a new study shows. The research, from investigators at the Waisman Center, University of Wisconsin-Madison, provides an atlas of early brain development in Down syndrome that could inform potential targeted treatments to address the developmental and degenerative aspects of the condition.

Taking out the trash: New study finds clearing specific cell “trash” is possible and may be target for future treatments of neurodegenerative diseases

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Cells make a lot of trash. Probably more than you’d think. So, cells have a trash disposal system that efficiently cleans up and recycles any waste that is produced. But when there are issues with the disposal system and trash builds up in the cell, that can lead to disease. This has led researchers to consider the trash disposal system as a target for potential disease treatments and therapies.

Anita Bhattacharyya, PhD – Slide of the Week

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Down syndrome (DS, trisomy 21) is characterized by intellectual impairment at birth and Alzheimer’s disease (AD) pathology in middle age. As individuals with DS age, their cognitive functions decline as they develop AD pathology.