Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Women who have a child with fragile X syndrome (FXS) and are themselves carriers of a “premutation” in the gene linked to FXS are at an increased risk of developing depression and certain kinds of anxiety disorders over time, according to a recent study by researchers at the Waisman Center and the University of South Carolina.
Legend: Top: A-B. 3D rendering of structured illumination microscopy (SIM) images of a human forebrain neuron growth cone triple-labeled for F-actin (red), ßIII tubulin (blue) and ADAM17 (green). A view of the apical surface (A) shows an F-actin foci in the central domain (arrowhead), which is revealed to be an apically directed protrusion in a lateral …
Legend: Left image: Children chronically at-risk for sensory processing disorders are more likely to have lower birthweight, lower gestational age, less sootheable and more fearful temperaments as toddlers. Right image: Severity of Age 4 sensory related behaviors (tactile sensitivity, auditory sensitivity, and movement) vary by risk for sensory processing disorders assessed at ages 2 and 7 …
Title: Pharmacological modulation of photoreceptor outer segment degradation in Best disease patient-derived hiPSC-RPE Legend: (a) Representative western blot analysis comparing the amount of the POS protein RHO in untreated and VPA-treated (500 µmol/l) BD hiPSC-RPE at 0 and 24 hours after POS feeding. (b) Quantification of RHO levels 24 hours after POS feeding in untreated versus …
