Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Re-expression of Halo-TSC2 for 1 DIV in TSC2-/- cortical neurons reduces hyper-phosphorylated S6 and increased neurite length
The microenvironment of developing neurons is a dynamic landscape of both chemical and mechanical cues that regulate cell proliferation, differentiation, migration, and axon extension.
Photoreceptors (PRs) are the primary visual sensory cells, and their loss leads to blindness that is currently incurable. Although cell replacement therapy holds promise, success is hindered by our limited understanding of PR axon growth during development and regeneration.
Legend: Top: A-B. 3D rendering of structured illumination microscopy (SIM) images of a human forebrain neuron growth cone triple-labeled for F-actin (red), ßIII tubulin (blue) and ADAM17 (green). A view of the apical surface (A) shows an F-actin foci in the central domain (arrowhead), which is revealed to be an apically directed protrusion in a lateral …
From his sixth-floor laboratory in the University of Wisconsin Waisman Center, Su-Chun Zhang, MD, PhD, has a unique vantage point on the second tower of the Wisconsin Institutes for Medical Research (WIMR II), which is nearing completion.
