Eye-gaze methods offer numerous advantages for studying cognitive processes in children with autism spectrum disorder (ASD), but data loss may threaten the validity and generalizability of results. Some eye-gaze systems may be more vulnerable to data loss than others, but to our knowledge, this issue has not been empirically investigated. In the current study, we asked whether automatic eye-tracking and manual gaze coding produce different rates of data loss or different results in a group of 51 toddlers with ASD.
Month: June 2020
Ari Rosenberg, PhD – Slide of the Week
Reconstructing three-dimensional (3D) scenes from two-dimensional (2D) retinal images is an ill-posed problem. Despite this, 3D perception of the world based on 2D retinal images is seemingly accurate and precise. The integration of distinct visual cues is essential for robust 3D perception in humans, but it is unclear whether this is true for non-human primates (NHPs).
Balancing act: what motor function can tell us about autism
Can the way a person moves be a key identifier of autism? It’s a question that Waisman Center investigator Brittany Travers, PhD, is trying to answer.
Luigi Puglielli, MD, PhD – Slide of the Week
Nε-lysine acetylation of nascent glycoproteins within the endoplasmic reticulum (ER) lumen regulates the efficiency of the secretory pathway. The ER acetylation machinery consists of the membrane transporter, acetyl-CoA transporter 1 (AT-1/SLC33A1), and two acetyltransferases, ATase1/NAT8B and ATase2/NAT8. Dysfunctional ER acetylation is associated with severe neurological diseases with duplication of AT-1/SLC33A1 being associated with autism spectrum disorder, intellectual disability, and dysmorphism.
Ben Parrell, PhD – Slide of the Week
When auditory feedback is perturbed in a consistent way, speakers learn to adjust their speech to compensate, a process known as sensorimotor adaptation. Typically, feedback perturbation experiments employ a transformation that targets a single vowel, or that affects all vowels in the same way, resulting in a uniform change across the vowel space.