Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
The extent to which amyloid-β burden and neurofibrillary tau tangle burden are associated with synaptic degeneration in vivo is not well known.
Our inability to derive the neuronal diversity that comprises the posterior central nervous system (pCNS) using human pluripotent stem cells (hPSCs) poses an impediment to understanding human neurodevelopment and disease in the hindbrain and spinal cord.
Structural pathologies, such as brain, are present at birth in Down syndrome (trisomy 21), reflecting embryonic origins that are generally associated with smaller organs or reduced growth.
White matter (WM) degeneration is a critical component of early Alzheimer's disease (AD) pathophysiology.
Cultural differences in environmental auditory ecology are usually studied using geographic area monitoring.
Fragile X messenger ribonucleoprotein 1 protein (FMRP) binds many mRNA targets in the brain. The contribution of these targets to fragile X syndrome (FXS) and related autism spectrum disorder (ASD) remain unclear.
Opening the door to university health research: recommendations for increasing accessibility for individuals with intellectual disability
Using a community-based participatory research framework, we piloted Duet, a preventative, parent-implemented, early language intervention.
Imaging-based quantitative measures from diffusion-weighted MRI (dMRI) offer the ability to non-invasively extract microscopic information from human brain tissues.
Autism spectrum disorder (ASD) has a consistent 4:1 male prevalence, suggesting a role for sex-differential biology in risk.
