Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Our machine-learning framework, brain and organoid manifold alignment (BOMA), first performs a global alignment of developmental gene expression data between brains and organoids.
Atypical vowel production contributes to reduced speech intelligibility in children and adults with Down syndrome (DS)
The goal of this research was to determine how sensory features, such as increased or decreased sensitivity to the environment, are associated with the brainstem in autistic and non-autistic children
Schwann cells play a critical role after peripheral nerve injury by clearing myelin debris, forming axon-guiding bands of Büngner, and remyelinating regenerating axons.
Expressive language impairments are common among school-age boys with fragile X syndrome (FXS) and autistic boys.
The granular dorsolateral prefrontal cortex (dlPFC) is an evolutionary specialization of primates that is centrally involved in cognition. We assessed more than 600,000 single-nucleus transcriptomes from adult human, chimpanzee, macaque, and marmoset dlPFC.
This study examines the relationship between the early identification of hearing loss and language outcomes for deaf/hard of hearing (D/HH) children, with bilateral or unilateral hearing loss and with or without additional disabilities.
Leber Congenital Amaurosis (LCA16) is a progressive vision loss disorder caused by point mutations in the KCNJ13 gene, which encodes an inward-rectifying potassium channel, Kir7.1.
Online data collection methods pose unique challenges and opportunities for infant researchers.
N ε-lysine acetylation within the lumen of the endoplasmic reticulum is a recently characterized protein quality control system that positively selects properly folded glycoproteins in the early secretory pathway.
