Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Neurite initiation from newly born neurons is a critical step in neuronal differentiation and migration.
Matt Zammit, PhD, Waisman scientist in the Brain Imaging Core, and affiliate investigator Erik Dent, PhD, are both winners of UW-Madison’s Cool Science Image Contest.
Dendritic spines, the mushroom-shaped extensions along dendritic shafts of excitatory neurons, are critical for synaptic function and are one of the first neuronal structures disrupted in neurodevelopmental and neurodegenerative diseases.
Title: KIF1A dynamically colocalizes with syt-IV and invades dendritic spines along microtubules. Legend: (a) eGFP-KIF1A colocalizes with mCherry-syt-IV in the dendritic shaft and moves together over time as detected in time-lapse images and in kymographs (scale bar, 5 mm). (b) Kymographs demonstrating that KIF1A (green arrows) does not colocalize with mitochondria (red arrow) in the …
