Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Title: Increasing Nrf2 activity in astrocytes confers protection to Nrf2 knockout neurons Legend: Nrf2 KO cultures were traduced with 50 MOI adenovirus-Nrf2-GFP or adenovirus-GFP 48 hours prior to H2O2 treatment. Cultures were immunohistochemically analyzed following treatment with 50 µM H2O2. Neuronal marker, beta(III)-tubulin (red), eGFP (green); Hoechst 3258 (blue). Citation: Kraft, A.D., Johnson, D.A. and J.A. Johnson (2004). Nrf2-dependent ARE …
In a finding that may cause a dramatic shift in the way scientists and researchers search for a therapy for Alzheimer’s disease, a team of researchers led by Jeff Johnson, an associate professor at the School of Pharmacy, has discovered that increased expression of a protein called transthyretin in the brain appears to halt the progression of the disease.
Scientists working with cells that may someday be used to replace diseased or damaged cells in the brain have taken neural stem cell technology a key step closer to the clinic.
