University of Wisconsin–Madison

Tag: STAT3

Tracy L. Hagemann, PhD – Slide of the Week

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Alexander disease (AxD) is caused by mutations in the gene for glial fibrillary acidic protein (GFAP), an intermediate filament expressed by astrocytes in the central nervous system.

We need to know STAT: Mechanisms behind GFAP accumulation in Alexander disease involve transcription factor STAT3.

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The hallmarks of Alexander disease, aggregation of misfolded GFAP proteins and dysregulation of brain cells called astrocytes, may be stopped and reversed in rodent models with the inactivation of the transcription factor STAT3.