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  1. Home
  2. Tag: GFAP

GFAP

Tracy L. Hagemann, PhD & Albee Messing, VMD, PhD – Slide of the Week

Posted on March 6, 2020

Alexander disease results from gain of function mutations in the gene encoding glial fibrillary acidic protein (GFAP). At least eight GFAP isoforms have been described, however, the predominant alpha isoform accounts for approximately 90% of GFAP protein.

Posted in Slide of the WeekTagged Alexander disease, GFAP, Tracy Hagemann

Mutation in common protein triggers tangles, chaos inside brain cells

Posted on October 23, 2018

In a study published today, Waisman Center investigators Su-Chun Zhang, Albee Messing and colleagues point to new understandings of the broad range of effects that result from the GFAP mutation impacting astrocytes — important supporting …

Posted in 2018, Neurodegenerative, News, Rare Disorders, Stem Cells, YearTagged Albee Messing, Alexander disease, GFAP, Stem Cells, Su-Chun Zhang

Su-Chun Zhang, MD, PhD

Posted on August 14, 2017

Alexander disease patient astrocytes have impaired calcium wave propagation Legend: A) Still images over time from mechanical stimulation of 6-month astrocytes loaded with Fluor-4AM and accompanying post-experiment GFAP stains. B) Average duration of increased calcium …

Posted in Slide of the WeekTagged Alexander disease, GFAP, Slide of the Week, Su-Chun Zhang

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