The hallmarks of Alexander disease, aggregation of misfolded GFAP proteins and dysregulation of brain cells called astrocytes, may be stopped and reversed in rodent models with the inactivation of the transcription factor STAT3.
Messing wanted to study if the overexpression of GFAP resulted in a certain reactive response in the brain.
Two Waisman investigators were recently awarded a new professor title track at UW-Madison.
Alexander disease is a progressive and rare neurological disorder with no cure or standard course of treatment. But a new study led by researchers at the University of Wisconsin–Madison involving a rat model of the disease offers a potential treatment for the typically fatal condition.
The Waisman Center, University of Wisconsin-Madison, launched a new fund to support interdisciplinary research in the area of intellectual and developmental disabilities (IDD) genomics.
In a study published today, Waisman Center investigators Su-Chun Zhang, Albee Messing and colleagues point to new understandings of the broad range of effects that result from the GFAP mutation impacting astrocytes — important supporting …
Picture a crisp October morning in Madison, Wisconsin – the bright colors of fall leaves, mists over the blue waters of Lake Mendota and – on one Sunday (the 14th this year) – a crowd of excited people waiting to run, walk or roll in the 2018 Waisman Whirl for ALL Abilities!
After more than a decade of work, researchers at the University of Wisconsin–Madison’s Waisman Center reported promising results in the lab and in animal models that could set the stage for developing a treatment for Alexander disease, a rare and usually fatal neurological disease with no known cure.
Waisman Center Director, Albee Messing, is collaborating with researchers at the Children’s Hospital of Philadelphia to better understand the progression of Alexander disease, a rare and fatal neurological disorder with no known cure. In …
Waisman Center Director, Albee Messing, VMD, PhD, was recently featured in the Know Your Madisonian column by David Wahlberg in the Wisconsin State Journal. To read the full interview, please click here. David Wahlberg, Wisconsin …