Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
The lab of Waisman Center director, Qiang Chang, PhD, professor of medical genetics and neurology, has received $1 million in funding from the Department of Defense to study the dysfunction of astrocytes, a key brain cell that supports neurons, in Rett syndrome.
The hallmarks of Alexander disease, aggregation of misfolded GFAP proteins and dysregulation of brain cells called astrocytes, may be stopped and reversed in rodent models with the inactivation of the transcription factor STAT3.
Long considered to be little more than putty in the brain and spinal cord, the star-shaped astrocyte has found new respect among neuroscientists who have begun to recognize its many functions in the brain, not to mention its role in a range of disorders of the central nervous system.
