Applying a dramatically improved method for “editing” genes to human stem cells, University of Wisconsin-Madison neuroscientist and Waisman Center investigator Su-Chun Zhang has shown a new way to silence genes in stem cells and their progeny at any stage of development.
Su-Chun Zhang
ALS awareness month
May is ALS awareness month and Waisman Center investigator Su-Chun Zhang, MD, PhD, uses stem cells from ALS patients to uncover the cause of ALS and screen drugs to treat the disease. Amyotrophic lateral sclerosis …
Laying a foundation for treating ALS, spinal cord injury
This story starts in 1955, upon the death of Albert Einstein, when the pathologist charged with performing the famous scientist’s autopsy stole his brain. Fast forward to the 1980s when a University of California, Berkeley scientist was studying parts of the stolen goods involved in complex thinking and discovered that the father of relativity had more of certain types of cells, called astrocytes, than other human brains studied.
Hearing research at the Waisman Center
More than 278 million people are affected by hearing loss caused by damaged hair cells in the inner ear that process sound to the brain. Waisman Center scientists work to research novel treatments and therapies for individuals with hearing loss that include stem cell research and cochlear implants.
ALS community suddenly awash in awareness
If you hadn’t heard of ALS before this summer, you’re not alone. If you haven’t heard of it by now, you must be living under a rock. Not only did the ubiquitous ALS Ice Bucket Challenge raise about $100 million from late July to late August, it boosted awareness of ALS, or amyotrophic lateral sclerosis, also known as Lou Gehrig’s disease.
Study helps unravel the tangled origin of ALS
By studying nerve cells that originated in patients with a severe neurological disease, a University of Wisconsin-Madison researcher has pinpointed an error in protein formation that could be the root of amyotrophic lateral sclerosis.
Busta benefit has record-setting year, generates $55,000
The 11th annual David Busta Basketball Tournament and Silent Auction once again proved successful as the benefit attracted many families, friends and community members to the Chetek-Weyerhaeuser High School Saturday, Nov. 30. After raising $26,000 …
Su-Chun Zhang has a unique view of Wisconsin Institutes for Medical Research
From his sixth-floor laboratory in the University of Wisconsin Waisman Center, Su-Chun Zhang, MD, PhD, has a unique vantage point on the second tower of the Wisconsin Institutes for Medical Research (WIMR II), which is nearing completion.
Waisman scientists model human disease in stem cells
Many scientists use animals to model human diseases. Mice can be obese or display symptoms of Parkinson’s disease. Rats get Alzheimer’s and diabetes. But animal models are seldom perfect, and so scientists are looking at a relatively new type of stem cell, called the induced pluripotent stem cell (iPS cell), that can be grown into specialized cells that become useful models for human disease.
Adult cells transformed into early-stage nerve cells, bypassing the pluripotent stem cell stage
A University of Wisconsin-Madison research group has converted skin cells from people and monkeys into a cell that can form a wide variety of nervous-system cells — without passing through the do-it-all stage called the induced pluripotent stem cell, or iPSC.