The granular dorsolateral prefrontal cortex (dlPFC) is an evolutionary specialization of primates that is centrally involved in cognition. We assessed more than 600,000 single-nucleus transcriptomes from adult human, chimpanzee, macaque, and marmoset dlPFC.
André Sousa
New Machine Learning Tool Helps Researchers Demonstrate Effectiveness of Stem Cell Based Models
Today, many researchers are using brain organoids – miniaturized and simplified versions of organs produced in a dish typically from stem cells – as analogs for studying the development of the human brain.
Study shows differences between brains of primates — humans, apes and monkeys — are small but significant
While the physical differences between humans and non-human primates are quite distinct, a new study reveals their brains may be remarkably similar. And yet, the smallest changes may make big differences in developmental and psychiatric disorders.
Four Waisman investigators receive prestigious Simons Foundation award to study autism
Four Waisman Center investigators will dig deeper into the function of genes implicated in autism and brain development with support from the prestigious Simons Foundation 2022 Pilot Award.
André Sousa, PhD – Slide of the Week
Title: Single-cell gene expression analysis reveals signatures of adult neurogenesis in mouse, pig and macaque, but not in humans. Legend: A) Schematic of the analytic workflow. DG: dentate gyrus; CA: cornu ammonis; Sub: subiculum; EC: entorhinal …
Stem cell project to create new model to study brain development and Down syndrome
Waisman Center researchers are creating a new approach to study how changes to brain development in the womb result in intellectual disability in people with Down syndrome.
Second seat in Waisman cluster hire filled by neuroscientist André Sousa
Sousa is the second hire in the cluster initiative that includes a biostatistician, a neuroscientist, and a geneticist.
André Sousa, PhD – Slide of the Week
Human nervous system development is an intricate and protracted process that requires precise spatiotemporal transcriptional regulation. We generated tissue-level and single-cell transcriptomic data from up to 16 brain regions covering prenatal and postnatal rhesus macaque development.