The prefrontal cortex (PFC) is critical for myriad high-cognitive functions and is associated with several neuropsychiatric disorders.
André Sousa
What research has revealed about Down syndrome’s influence on brain development
A new review paper published in Nature Reviews Neuroscience from Bhattacharyya, associate professor of cell and regenerative biology, pulls together what is currently known about DS’s impact on brain development.
Waisman Center IDDRC funds three pilot projects on novel Down syndrome research
Three Waisman Center investigators and affiliates were awarded an internal grant to support Down syndrome research in its early stages. The funds were made possible through the Ann Dewey Down Syndrome Catalyst Fund at the Waisman Center.
André Sousa, PhD – Slide of the Week
The granular dorsolateral prefrontal cortex (dlPFC) is an evolutionary specialization of primates that is centrally involved in cognition. We assessed more than 600,000 single-nucleus transcriptomes from adult human, chimpanzee, macaque, and marmoset dlPFC.
Waisman Investigator Receives Prestigious Cajal Club Krieg Cortical Explorer Award
André Sousa, PhD, Waisman Center investigator and assistant professor of neuroscience, didn’t even realize he had received the Cajal Club’s Krieg Cortical Explorer Award.
UW effort to map Down syndrome brain raises prospect of treatment for disorder
In a lab near UW Hospital, Megan Jandy grows stem cells from people with Down syndrome — 10 batches of cells, most in three-dimensional clusters, each batch featuring one group with the extra chromosome that causes the disorder and one group without it.
Genomics and genetics cluster hire brings expansion into new research avenues
Tiny but mighty is a good way of describing our genome – the collection of our DNA. Although not visible to the naked eye, the human genome holds around 21,000 genes and millions of DNA variants, containing the information needed to maintain an organism throughout its life.
André Sousa, PhD – Slide of the Week
The granular dorsolateral prefrontal cortex (dlPFC) is an evolutionary specialization of primates that is centrally involved in cognition. We assessed more than 600,000 single-nucleus transcriptomes from adult human, chimpanzee, macaque, and marmoset dlPFC.
New machine learning tool helps researchers demonstrate effectiveness of stem cell based models
Today, many researchers are using brain organoids – miniaturized and simplified versions of organs produced in a dish typically from stem cells – as analogs for studying the development of the human brain.
Study shows differences between brains of primates — humans, apes and monkeys — are small but significant
While the physical differences between humans and non-human primates are quite distinct, a new study reveals their brains may be remarkably similar. And yet, the smallest changes may make big differences in developmental and psychiatric disorders.