André Sousa, PhD, Waisman Center investigator and assistant professor of neuroscience, didn’t even realize he had received the Cajal Club’s Krieg Cortical Explorer Award.
In a lab near UW Hospital, Megan Jandy grows stem cells from people with Down syndrome — 10 batches of cells, most in three-dimensional clusters, each batch featuring one group with the extra chromosome that causes the disorder and one group without it.
Tiny but mighty is a good way of describing our genome – the collection of our DNA. Although not visible to the naked eye, the human genome holds around 21,000 genes and millions of DNA variants, containing the information needed to maintain an organism throughout its life.
The granular dorsolateral prefrontal cortex (dlPFC) is an evolutionary specialization of primates that is centrally involved in cognition. We assessed more than 600,000 single-nucleus transcriptomes from adult human, chimpanzee, macaque, and marmoset dlPFC.
Today, many researchers are using brain organoids – miniaturized and simplified versions of organs produced in a dish typically from stem cells – as analogs for studying the development of the human brain.
While the physical differences between humans and non-human primates are quite distinct, a new study reveals their brains may be remarkably similar. And yet, the smallest changes may make big differences in developmental and psychiatric disorders.
Four Waisman Center investigators will dig deeper into the function of genes implicated in autism and brain development with support from the prestigious Simons Foundation 2022 Pilot Award.
Title: Single-cell gene expression analysis reveals signatures of adult neurogenesis in mouse, pig and macaque, but not in humans. Legend: A) Schematic of the analytic workflow. DG: dentate gyrus; CA: cornu ammonis; Sub: subiculum; EC: entorhinal …
Waisman Center researchers are creating a new approach to study how changes to brain development in the womb result in intellectual disability in people with Down syndrome.
Sousa is the second hire in the cluster initiative that includes a biostatistician, a neuroscientist, and a geneticist.