When nerves are injured, Schwann cells—a key cell in peripheral nerve function and nerve insulation—assume a new role and identity as repair cells.
John Svaren
John Svaren, PhD – Slide of the Week
The goal of this proposal was to determine if microRNA’s (miR) are elevated in the plasma of individuals affected by the inherited peripheral neuropathy Charcot-Marie-Tooth Disease, type 1A (CMT1A)
CMT biomarkers for future treatments
A new test may spur advances in drug discovery for a rare and debilitating neurological disorder. Charcot-Marie-Tooth disease, a rare inherited neurological disorder, affects more than 2.8 million people around the globe.
CMT advocate will not be sidelined
CMT is equally common among all ages, genders, and races and is one of the most common heritable neurological impairments. The symptoms present as neuropathy, foot drop, poor balance, difficulty with dexterity, or abnormal sensation – just to name a few.
John Svaren, PhD – Slide of the Week
Our goal was to define the genetic cause of the profound hypomyelination in the taiep rat model and determine its relevance to human white matter disease.
Proposals by Waisman investigators selected for UW-Madison Cluster Hire Initiative
Several Waisman Center investigators played key roles in crafting research proposals that were recently selected as ‘cluster hires’ by the University of Wisconsin-Madison. UW–Madison’s Cluster Hiring Initiative was launched in 1998 as an innovative partnership …
John Svaren, PhD
Peripheral nerve regeneration after injury is dependent upon implementation of a novel genetic program in Schwann cells that supports axonal survival and regeneration.
Better understanding a devastating neurological disease
Waisman Center investigator John Svaren collaborated with Ian Duncan, a professor of veterinary medicine at the University of Wisconsin–Madison, and others on a study that offers new insight into a rare human disease, called H-ABC, …
A case of (peripheral) nerves
Every day, Waisman Center researcher John Svaren deals with nerves – peripheral nerves, that is. Peripheral nerves connect the brain and spinal cord to our limbs and organs, serving as vital communication relays that allow …
John Svaren, PhD
Title: The Sox10 transcriptional regulator binds genes important for myelin formation in both oligodendrocytes of the spinal cord and Schwann cells in peripheral nerves. Legend: The diagram shows data from next generation sequencing techniques (known …