Waisman Center researchers are creating a new approach to study how changes to brain development in the womb result in intellectual disability in people with Down syndrome.
Daifeng Wang
A new computational pipeline connects disease and discovery at the cellular level
Could Alzheimer’s disease and schizophrenia be biologically connected?
Daifeng Wang, PhD – Slide of the Week
Understanding cell-type-specific gene regulatory mechanisms from genetic variants to diseases remains challenging. To address this, we developed a computational pipeline, scGRNom (single-cell Gene Regulatory Network prediction from multi-omics), to predict cell-type disease genes and regulatory networks including transcription factors and regulatory elements.
Daifeng Wang, PhD – Slide of the Week
The molecular mechanisms and functions in complex biological systems currently remain elusive. Recent high-throughput techniques, such as next-generation sequencing, have generated a wide variety of multiomics datasets that enable the identification of biological functions and mechanisms via multiple facets. However, integrating these large-scale multiomics data and discovering functional insights are, nevertheless, challenging tasks.
New Researcher Uses Machine Learning to Decode Genomic Information
Recent advances in genome sciences — the study of an organism’s complete set of DNA — present a golden opportunity to identify the genetic causes and underlying mechanisms of intellectual and developmental disabilities. These discoveries …