Fragile X syndrome results from a loss of the RNA-binding protein fragile X mental retardation protein (FMRP). How FMRP regulates neuronal development and function remains unclear. Here we show that FMRP-deficient immature neurons exhibit impaired dendritic maturation, altered expression of mitochondrial genes, fragmented mitochondria, impaired mitochondrial function, and increased oxidative stress.
Slide of the Week
Houri K. Vorperian, PhD – Slide of the Week
The size and shape of human cervical vertebral bodies serve as a reference for measurement or treatment planning in multiple disciplines. It is therefore necessary to understand thoroughly the developmental changes in the cervical vertebrae in relation to the changing biomechanical demands on the neck during the first two decades of life.
Brittany Travers, PhD – Slide of the Week
Individuals with autism spectrum disorder often struggle with motor difficulties across the life span, and these motor difficulties may affect independent living skills and quality of life. Yet, we know little about how whole-body movement may distinguish individuals with autism spectrum disorder from individuals with typical development.
Ender Tekin, PhD – Slide of the Week
Loss of vision can frequently lead to a loss of independence and a reduction in quality of life for an individual. The Tekin lab is interested in harnessing new mobile technologies to provide access to environmental information for persons with vision loss.
John Svaren, PhD – Slide of the Week
Peripheral nerve myelination is adversely affected in the most common form of the hereditary peripheral neuropathy called Charcot-Marie-Tooth Disease. This form, classified as CMT1A, is caused by a 1.4 Mb duplication on chromosome 17, which includes the abundantly expressed Schwann cell myelin gene, Peripheral Myelin Protein 22 (PMP22).
Masatoshi Suzuki, DVM, PhD – Slide of the Week
Human induced pluripotent stem cells (iPSCs) present exciting opportunities to study disease processes in vitro. Advances in bioengineering allow us to differentiate cells in a system more relevant to their native environment in order to observe naturally occurring phenomena.
Audra Sterling, PhD – Slide of the Week
This study investigated the production of demonstratives (e.g., this, that, these) and personal pronouns in school-age boys with idiopathic autism spectrum disorder (ASD) and school-age boys with fragile X syndrome (FXS) with a co-diagnosis of ASD (FXS+ASD).
Kristin Shutts, PhD – Slide of the Week
Can brief messages about health influence children’s consumption of identical foods? Across a series of studies, we manipulated children’s consumption of identical foods (fruit sauces) by pairing those foods with brief messages about each food’s health status.
Lawrence D. Shriberg, PhD -Slide of the Week
The goals of this research were to obtain initial estimates of the prevalence of each of four types of motor speech disorders in children with idiopathic Speech Delay (SD) and to use findings to estimate the population-based prevalence of each disorder. Analyses were completed on audio-recorded conversational speech samples from 415 children recruited for research in idiopathic SD in six USA cities during the past three decades.
Karl S. Rosengren, PhD – Slide of the Week
Children’s drawings have long been used to assess aspects of general cognitive functioning, intelligence, perceptual motor development, and even socio-emotional development. The goal of the current study was to examine the structure of children’s drawings using crowd-sourced human similarity judgments and machine vision approaches.