Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Disciplines across the social and behavioral sciences have documented the critical role of early peer connections in children's development, yet mechanisms facilitating these connections have not been tested in controlled laboratory settings.
The human genome has many short tandem repeats, yet the normal functions of these repeats are unclear.
Title: Use of the new human telomere-to-telomere genomic reference improves variant calling and phasing in regions flanking developmental disorder-associated copy number variants Legend: Genotyping and switch error rates spike in areas flanking CNV disorder associated regions. Average error rates obtained when phasing short read variant calls from 39 individuals using either the T2T-CHM13 1KGP haplotype panel …
Parenting a child with a developmental disability can be a profound source of stress, particularly for mothers.
Cellular processes like development, differentiation, and disease progression are highly complex and dynamic (e.g., gene expression).
Although ALS has historically been characterized as a motor neuron disease, there is evidence that motor neurons degenerate in a retrograde manner, beginning in the periphery at the neuromuscular junctions (NMJs) and skeletal muscle.
...we found that the parvicellular reticular formation-alpha, a part of the brainstem thought to be involved in chewing, digesting food, heart rate, and breathing was related to individual differences in social communication in autistic children
Formation of myelin by Schwann cells is tightly coupled to peripheral nervous system development and is important for neuronal function and long-term maintenance.
The prefrontal cortex (PFC) is critical for myriad high-cognitive functions and is associated with several neuropsychiatric disorders.
Here, we report the spatial organization of RNA transcription and associated enhancer dynamics in the human spinal cord at single-cell and single-molecule resolution.
