Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Title: Skeletal muscle cells derived from human pluripotent stem cells Legend: Suzuki lab recently initiated a new project to establish skeletal muscle progenitor/stem cells derived from human pluripotent sources. Our culture method can produce skeletal muscle progenitor cells from human pluripotent stem cells generated from both healthy donors and patients with neuromuscular disorders. Such differentiated …
A University of Wisconsin—Madison neuroscientist has inserted a genetic switch into nerve cells so a patient can alter their activity by taking designer drugs that would not affect any other cell.
A University of Wisconsin-Madison researcher who studies the most common genetic intellectual disability has used an experimental drug to reverse—in mice—damage from the mutation that causes the syndrome.
An innovative project led by Waisman Center researchers Anita Bhattacharyya and Su-Chun Zhang is one of fourteen research initiatives that have been chosen for the first round of funding by the University of Wisconsin-Madison Office of the Vice Chancellor for Research and Graduate Education for the UW2020: WARF Discovery Initiative.
Su-Chun Zhang, a pioneer in developing neurons from stem cells at the University of Wisconsin-Madison, has created a specialized nerve cell that makes serotonin, a signaling chemical with a broad role in the brain. Serotonin affects emotions, sleep, anxiety, depression, appetite, pulse and breathing. It also plays a role in serious psychiatric conditions like schizophrenia, …
A team of eye researchers at the University of Wisconsin-Madison have used a custom stem cell model of a rare but blinding eye disease to test whether a commonly used drug might offer hope for treatment.
In his 19-year career at UW–Madison, Dr. Su-Chun Zhang has transformed the field of stem cell research. The renowned neuroscientist was the first in the world to isolate neural stem cells from embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), a landmark discovery he patented with the help of the Wisconsin Alumni Research Foundation (WARF) in 2001.
The news that legendary Green Bay Packer quarterback Bart Starr has undergone stem cell therapy to recover from a stroke has raised the profile for a promising but unproven regenerative treatment intended to replace dead neurons with live ones.
Applying a dramatically improved method for "editing" genes to human stem cells, University of Wisconsin-Madison neuroscientist and Waisman Center investigator Su-Chun Zhang has shown a new way to silence genes in stem cells and their progeny at any stage of development.
Title: Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis Legend: Representative images (left) of adult neural progenitor cells (aNPCs) isolated from wild type (WT) and Mecp2S421A;S424A/y hippocampus with BrdU pulse labeling, followed by immunocytochemistry analysis. (middle) Representative images of Tuj1+ neurons differentiated from WT and Mecp2S421A;S424A/y aNPCs. (right) Representative images of GFAP+ astrocyte differentiated from WT and …
