Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Perinatal brain injury is a primary cause of cerebral palsy, a condition resulting in life-long motor impairment.
g-aminobutyric acid type A receptors that incorporate a5 subunits (a5-GABAARs) are highly enriched in the hippocampus and they are strongly implicated in the control of learning and memory.
Speakers were presented with different auditory perturbations to both vowels in the word “bedhead” (left panel); one vowel was altered toward the vowel /æ/ (“had”) and the other toward /ɪ/ (“hid”), with the order balanced across participants.
Title: A single exposure to altered auditory feedback causes observable sensorimotor adaptation in speech Legend: A: The average first formant frequency (F1) trajectory for vowels that were spoken during (“compensation”; at left) or immediately after (“one-shot adaptation”; at right) a perturbation to auditory feedback that shifted F1 up (blue) or down (red). B: The probability …
Alexander disease (AxD) is a devastating leukodystrophy caused by gain-of-function mutations in GFAP, and the only available treatments are supportive. Recent advances in antisense oligonucleotide (ASO) therapy have demonstrated that transcript targeting can be a successful strategy for human neurodegenerative diseases amenable to this approach.
Title: Association between FMR1 CGG Repeat Number Polymorphism and Phenotypic Variation in the General Population Legend: Associations between CGG repeat lengths and phenotypes. (A) Linear association with IQ. (B) Linear association with college graduate (males only). (C) Curvilinear association with age at menopause (females only). (D) Curvilinear association with the number of biological children (females only). (E) …
Title: A Gene‐Environment Interaction Study of Polygenic Scores and Maltreatment on Childhood ADHD Legend: The interaction between a categorized ADHD polygenic score (PGS) and maltreatment factor score was insignificant, although the main effects of both were statistically significant (not shown). Not shown: The categorized ADHD PGS was derived based on an empirically tested cut-point that …
Our knowledge to date about structural brain development across the lifespan in ASD comes mainly from cross-sectional studies, thereby limiting our understanding of true age effects within individuals with the disorder that can only be gained through longitudinal research.
Our knowledge to date about structural brain development across the lifespan in ASD comes mainly from cross-sectional studies, thereby limiting our understanding of true age effects within individuals with the disorder that can only be gained through longitudinal research.
The current study examined language control and code-switching in bilingual children with Developmental Language Disorder (DLD) compared to bilingual peers with typical language development (TLD). In addition, proficiency in each language and cognitive control skills were examined as predictors of children’s tendency to engage in cross-speaker and intra-sentential code-switching.
