Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Title: Anatomic development of the upper airway during the first five years of life: A three-dimensional imaging study Legend: Illustration of the airway regions and measurements. The four airway regions [Nasopharynx (blue); Oropharynx (red); Laryngopharynx (cyan); and Subglottal region (magenta)] bounded by five cross sectional areas (a-to-d) as depicted in the right panel, were quantified …
The goal of this proposal was to determine if microRNA’s (miR) are elevated in the plasma of individuals affected by the inherited peripheral neuropathy Charcot-Marie-Tooth Disease, type 1A (CMT1A)
The goal of this proposal was to determine if microRNA’s (miR) are elevated in the plasma of individuals affected by the inherited peripheral neuropathy Charcot-Marie-Tooth Disease, type 1A (CMT1A)
Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disease in which patients gradually become paralyzed due to loss of motor function. Many genetically inheritable mutations have been linked to ALS; however, the majority of ALS patients are considered sporadic.
This study examined the extent to which early intervention (EI) speech-language pathologists (SLPs) use and recommend language input strategies for caregivers of children with language delays and the child factors associated with these decisions.
Title: Single-cell gene expression analysis reveals signatures of adult neurogenesis in mouse, pig and macaque, but not in humans. Legend: A) Schematic of the analytic workflow. DG: dentate gyrus; CA: cornu ammonis; Sub: subiculum; EC: entorhinal cortex B) Seurat integration of all cells in the dentate gyrus (each dot represents one cell). RGL: radial glia-like cell; …
Biomedical research has been revolutionized by the introduction of many CRISPR-Cas systems that induce programmable edits to nearly any gene in the human genome.
Title: Toddlers make use of speaker’s genders while listening to words Legend: Toddlers viewed pairs of familiar objects selected to be prototypically male or female. As they listened to words referring to these objects, we tracked their eye gaze. Toddlers were faster to fixate prototypically-gendered objects when they heard a voice from the same gender …
Learning the value of environmental signals and using that information to guide behavior is critical for survival. Stress in childhood may influence these processes, but how it does so is still unclear.
Endoplasmic reticulum-based Nɛ-lysine acetylation serves as an important protein quality control system for the secretory pathway.
