Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Title: Creation of a human reporter stem cell line for detecting fragile X mental retardation (FMR1) gene reactivation in human neural cells. Legend: Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability and a major genetic cause of autism. FXS is caused by mutational trinucleotide expansion in the FMR1 gene leading …
An innovative project led by Waisman Center researchers Anita Bhattacharyya and Su-Chun Zhang is one of fourteen research initiatives that have been chosen for the first round of funding by the University of Wisconsin-Madison Office of the Vice Chancellor for Research and Graduate Education for the UW2020: WARF Discovery Initiative.
Title: iPSC-Derived Forebrain Neurons from FXS Individuals Show Defects in Initial Neurite Outgrowth Legend: Left panel: Skin cells from individuals with fragile X syndrome (FXS) can be reprogrammed into induced pluripotent stem cells (iPSCs) that have characteristics of human embryonic stem cells. These iPSCs can then be differentiated into forebrain cortical neurons to study neuronal …
Neil Heinen, WISC-TV editorial director, recently sat down with Marsha R. Mailick, PhD, Waisman Center Director, along with Anita Bhattacharyya, PhD, Senior Scientist and Maria Stanley, MD, Waisman Center Clinics Medical Director, to discuss the breadth of research and service that takes place at the Waisman Center. The discussion also highlighted the Waisman Center’s 40th …
Many scientists use animals to model human diseases. Mice can be obese or display symptoms of Parkinson's disease. Rats get Alzheimer's and diabetes. But animal models are seldom perfect, and so scientists are looking at a relatively new type of stem cell, called the induced pluripotent stem cell (iPS cell), that can be grown into specialized cells that become useful models for human disease.
