Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Title: Brief Report: Fast mapping predicts differences in concurrent and later language abilities in children with ASD. Legend: Receptive and expressive language at age 3½ and age 5½ by fast mapping profile group. PLS-4 = Preschool Language Scale, 4th Edition. Error bars represent one standard error. Left panel: At age 3½, poor learners had significantly lower receptive …
Title: Enhanced Prefrontal-Amygdala Connectivity Following Childhood Adversity as a Protective Mechanism Against Internalizing in Adolescence Legend: Childhood adversity predicts greater amygdala–medial prefrontal cortex (mPFC) functional connectivity (FC) in adolescence, but it is moderated by internalizing (Int) symptoms. Functional connectivity estimates were derived from the negative vs. neutral image contrast, using a seed-based approach. The seed …
Title: KIF1A dynamically colocalizes with syt-IV and invades dendritic spines along microtubules. Legend: (a) eGFP-KIF1A colocalizes with mCherry-syt-IV in the dendritic shaft and moves together over time as detected in time-lapse images and in kymographs (scale bar, 5 mm). (b) Kymographs demonstrating that KIF1A (green arrows) does not colocalize with mitochondria (red arrow) in the …
Title: Metabolomic analysis of CSF indicates brain metabolic impairment precedes hematological indices of anemia in the iron-deficient infant monkey. Legend: NMR spectra with typical metabolite peaks in the cerebrospinal fluid of one iron-sufficient (IS) and one iron-deficient (ID) rhesus monkey. Differences in citrate (cit), glutamine (gin), and pyruvate (pyr) indicate that brain energetics are affected …
Title: Altered flip/flop alternative splicing causes a reduction of the decay time constant of the AMPA receptor. Legend: (a) RNA-Seq analysis reveals a significant change of the relative flip/flop ratio of Gria2 in Mecp2 KO cortex. (b) qRT-PCR confirms the significant reduction of flip/flop ratio of Gria2 in Mecp2 KO. (c) qRT-PCR results show that …
Title: ERα Signaling Is Required for TrkB-Mediated Hippocampal Neuroprotection in Female Neonatal Mice after Hypoxic Ischemic Encephalopathy Legend: Increases in p-TrkB immuno and protein expressions are sexually differentiated and ERα dependent post-HI. A. Changes in MAP2 and p-TrkBY515 immunoexpression in the CL and IL hippocampi of ERα+/+ and ERα-/- P9 male and female mice were …
Title: Creation of a human reporter stem cell line for detecting fragile X mental retardation (FMR1) gene reactivation in human neural cells. Legend: Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability and a major genetic cause of autism. FXS is caused by mutational trinucleotide expansion in the FMR1 gene leading …
Title: Age-dependent differences in brain tissue microstructure assessed with neurite orientation dispersion and density imaging Legend: Healthy brain aging involves substantial changes to the structures that “wire up” the brain, including myelinated axons and dendritic connections. However, these changes and their impact on memory and other thinking skills are often difficult to measure in living …
Title: Presence, Proximity, and Peer Interactions of Adolescents with Severe Disabilities in General Education Classrooms Legend: Percentage of students with severe disabilities who are present in the general education classroom and in proximity to peers without severe disabilities by percentage of elapsed time in the class period. Citation: Feldman, R.L., Carter, E.W., Brock, M.E., & …
Title: Sensory Subtypes and Associated Outcomes in Children with Autism Spectrum Disorders Legend: Vineland Adaptive Behavior Scale 2nd Edition- adaptive behavior composite score, domains, and maladaptive score by sensory subtype (Mild Subtype, Sensitive-Distressed Subtype, Attenuated-Preoccupied Subtype, and Extreme-Mixed Subtype). Parenting Stress Index 3rd Edition, Short Form- total score, parental distress, difficult child, and parent/child dysfunctional …
