Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Remote access to tDCS mitigates barriers to treatment such as location, time, transportation, and finances. While only 14% of Americans live in rural communities, they represent nearly 2/3 of primary care health professional shortage areas. Telehealth visits cost patients on average 54% less costly for an office visit. Time and travel are estimated to cost patients about $89 billion a year.
Young children with severe traumatic brain injury (TBI) have frequently been excluded from studies due to age and/or mechanism of injury.
Endoplasmic reticulum-based Nɛ-lysine acetylation serves as an important protein quality control system for the secretory pathway.
g-aminobutyric acid type A receptors that incorporate a5 subunits (a5-GABAARs) are highly enriched in the hippocampus and they are strongly implicated in the control of learning and memory.
Speakers were presented with different auditory perturbations to both vowels in the word “bedhead” (left panel); one vowel was altered toward the vowel /æ/ (“had”) and the other toward /ɪ/ (“hid”), with the order balanced across participants.
Title: A single exposure to altered auditory feedback causes observable sensorimotor adaptation in speech Legend: A: The average first formant frequency (F1) trajectory for vowels that were spoken during (“compensation”; at left) or immediately after (“one-shot adaptation”; at right) a perturbation to auditory feedback that shifted F1 up (blue) or down (red). B: The probability …
Women with intellectual and developmental disabilities (IDD) face increased risk of adverse maternal pregnancy outcomes, yet less is known about infant outcomes.
Alzheimer's disease is characterized by accumulation of amyloid and neurofibrillary tangles, and this pathology can be detected using neuroimaging or fluid biomarkers prior to the development of dementia. The Alzheimer's disease process also involves neurodegeneration which eventually leads to cognitive decline and dementia, however typical approaches for measuring neurodegeneration (such as T1-weighted imaging), may not be sensitive to neurodegeneration in the asymptomatic disease stage.
There is substantial heterogeneity in the development of depression from adolescence into adulthood. Yet, little is known about the risk factors underlying its various patterns of development. For instance, despite the discovery of genetic variants for depression, these discoveries have not accounted for the high degree of genetic covariation between multiple disorders, nor have they been applied to disambiguate its heterogeneous developmental presentations.
Adults with Down syndrome (DS) are predisposed to Alzheimer’s disease (AD) and a characterization of glucose metabolism change throughout AD progression has yet to be performed in this population. Using FDG PET, regional glucose metabolism was evaluated across groups of cognitively stable DS (CS-DS), DS with mild cognitive impairment or Alzheimer’s disease (MCI-DS/AD), and healthy non-DS sibling controls.
