Title: Identification of FMR1-regulated molecular networks in human neurodevelopment Legend: Generation of FMR1-FLAG hPSCs using one-step seamless genome editing using CRISPR-Cas9, Neural differentiation of hPSCs into forebrain dorsal NPCs (dNPC) and ventral MGE-like NPCs (vNPC), …
Slide of the Week
Daifeng Wang, PhD – Slide of the Week
The molecular mechanisms and functions in complex biological systems currently remain elusive. Recent high-throughput techniques, such as next-generation sequencing, have generated a wide variety of multiomics datasets that enable the identification of biological functions and mechanisms via multiple facets. However, integrating these large-scale multiomics data and discovering functional insights are, nevertheless, challenging tasks.
Houri K. Vorperian, PhD – Slide of the Week
We present a unified heat kernel smoothing framework for modeling 3D anatomical surface data extracted from medical images. Due to image acquisition and preprocessing noises, it is expected the medical imaging data is noisy. The surface data of the anatomical structures is regressed using the weighted linear combination of Laplace-Beltrami (LB) eigenfunctions to smooth out noisy data and perform statistical analysis.
Masatoshi Suzuki, DVM, PhD – Slide of the Week
Amyotrophic lateral sclerosis (ALS) is a late-onset neuromuscular disease with no cure and limited treatment options. Patients experience a gradual paralysis leading to death from respiratory complications on average only 2-5 years after diagnosis.
Audra Sterling, PhD – Slide of the Week
Title: Comparing tense and agreement productivity in boys with fragile X syndrome, children with developmental language disorder, and children with typical development Legend: Pattern of tense and agreement productivity across boys with fragile X syndrome (FXS), …
Jenny Saffran, PhD – Slide of the Week
Eye-gaze methods offer numerous advantages for studying cognitive processes in children with autism spectrum disorder (ASD), but data loss may threaten the validity and generalizability of results. Some eye-gaze systems may be more vulnerable to data loss than others, but to our knowledge, this issue has not been empirically investigated. In the current study, we asked whether automatic eye-tracking and manual gaze coding produce different rates of data loss or different results in a group of 51 toddlers with ASD.
Ari Rosenberg, PhD – Slide of the Week
Reconstructing three-dimensional (3D) scenes from two-dimensional (2D) retinal images is an ill-posed problem. Despite this, 3D perception of the world based on 2D retinal images is seemingly accurate and precise. The integration of distinct visual cues is essential for robust 3D perception in humans, but it is unclear whether this is true for non-human primates (NHPs).
Niziolek Lab – Slide of the Week
Schwa is cross-linguistically described as having a variable target. The present study examines whether speakers are sensitive to whether their auditory feedback matches their target when producing schwa.
Jan Greenberg, PhD – Slide of the Week
Expressed emotion (EE) is a measure of the family’s emotional climate and has been shown to be associated with a range of symptoms and psychiatric outcomes in individuals with various disabilities. In addition, growing evidence suggests that high levels of family distress are associated with high EE.
H. Hill Goldsmith, PhD – Slide of the Week
We used Latent Profile Analyses to derive four profiles of infant temperament from 990 twins at 6 and 12 months of age using observed infant behavior. Parents reported on their own emotional experiences.