New Study Reveals Changes in Key Pathway in Down Syndrome

A new paper published by Anita Bhattacharyya, PhD, assistant professor of cell and regenerative biology at UW-Madison and a Waisman investigator, reveals that the differences in brain structure in individuals with Down syndrome (DS or Trisomy 21) may be due to disrupted signaling pathways that alter brain development to result in the incorrect number or placement of cells in the brain.

Bradley T Christian, PhD – Slide of the Week

Adults with Down syndrome (DS) are predisposed to Alzheimer’s disease (AD) and a characterization of glucose metabolism change throughout AD progression has yet to be performed in this population. Using FDG PET, regional glucose metabolism was evaluated across groups of cognitively stable DS (CS-DS), DS with mild cognitive impairment or Alzheimer’s disease (MCI-DS/AD), and healthy non-DS sibling controls.