Category: Alexander Disease

Progress made toward treatment for rare, fatal neurological disease

After more than a decade of work, researchers at the University of Wisconsin–Madison’s Waisman Center reported promising results in the lab and in animal models that could set the stage for developing a treatment for Alexander disease, a rare and usually fatal neurological disease with no known cure.

Madison County girl hopes to help unlock cure of rare disease

  Waisman Center Director, Albee Messing, is collaborating with researchers at the Children’s Hospital of Philadelphia to better understand the progression of Alexander disease, a rare and fatal neurological disorder with no known cure. In a news story in the Belleville News-Democrat, Messing said that the study has already led scientists to several breakthroughs in …

Know Your Madisonian: Albee Messing focuses on Alexander disease

Waisman Center Director, Albee Messing, VMD, PhD, was recently featured in the Know Your Madisonian column by David Wahlberg in the Wisconsin State Journal. To read the full interview, please click here. David Wahlberg, Wisconsin State Journal

Researchers make headway toward understanding Alexander disease

Researchers at the University of Wisconsin–Madison have made a surprising and potentially crucial discovery about Alexander disease, a rare and fatal neurological disorder with no known cure. Using a mouse model for this disease, which in humans involves the destruction of white matter in the brain, a research team led by Albee Messing, director of …

Thoughts of Gratitude: The Rijkaarts

May 18, 2016 Adityarup “Rup” Chakravorty, Waisman Communications Jelte Rijkaart is 10 years old, with a ready smile, dark brown hair and warm brown eyes. He enjoys hanging out with people, especially his brother Roan. He is passionate about clocks—he has a wall dedicated to cuckoo clocks—and enjoys all sorts of movies about clocks on …

Tracing a path towards neuronal cell death in Alexander disease

A fruit fly model of a rare, neurodegenerative disease is helping researchers trace the series of steps that lead to neuronal cell death. Damage to astrocytes - star-shaped cells found in the brain and spinal cord - is found in many neurodegenerative conditions, but it's been unclear exactly what role astrocyte dysfunction plays in the development of disease.

Messing named director of Waisman Center

Albee Messing, a University of Wisconsin–Madison professor of comparative biosciences and an international leader in research on Alexander disease, has been named director of the Waisman Center, UW–Madison School of Medicine and Public Health Dean Robert Golden announced April 14. Golden says Messing was selected for the position due to his unique combination of experience, …

Rare disease research and treatment

A rare disease can be isolating when few people have it and there is no cure.

Rare disease yields clues about broader brain pathology

Alexander disease is a devastating brain disease that almost nobody has heard of — unless someone in the family is afflicted with it. Alexander disease strikes young or old, and in children destroys white matter in the front of the brain.

After 40 years, Waisman Center still at forefront of research on the brain

The telegram from President John F. Kennedy to University of Wisconsin President Fred Harrington was both eerie and visionary. Eerie because it was delivered Nov. 20, 1963 – just two days before Kennedy was assassinated in Dallas – and visionary because it seemed to anticipate the challenges confronting science in its quest to explore the human brain.