Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
A new gene editing service provides researchers on campus with genetically engineered pluripotent stem cell lines derived using CRISPR-Cas9. The UW–Madison iPSC Reprogramming and Human Stem Cell Gene Editing Service is co-operated by the Waisman Center’s iPSC Core and led by investigators Anita Bhattacharyya and Su-Chun Zhang. The techniques and expertise that keep the service …
Su-Chun Zhang, a Waisman Center investigator, was the first person in the world to craft human brain cells both from human embryonic stem (ES) cells and later from induced pluripotent (iPS) cells. In a recent interview with UW–Madison, Zhang answers questions on his career in stem cell neuroscience and the challenges that stem cell research may …
Twenty years ago, a seminal discovery by researchers at UW–Madison introduced stem cells to the world. Since then, this new tool has transformed science and opened new doors for translational research. Stem cells are undifferentiated “master cells” capable of transforming into any of the body’s cell types. Waisman Center researchers have been at the forefront …
From five examples of human embryonic stem cells in 1998 to 1,364 different lines of stem cell cultures today, the field of stem cell research has come so far in the past 20 years. The Capital Times highlights stem cell research milestones, challenges and future prospects on the 20th anniversary of stem cell research at …
To mark the 20th anniversary of the stem cell discovery at UW–Madison, the Wisconsin State Journal featured a series of stories on stem cell research, highlighting the work of Waisman Center investigators David Gamm, Anita Bhattacharyya, Su-Chun Zhang, affiliate Randall Ashton, as well as Waisman Biomanufacturing. Researchers at the Waisman Center use stem cells— undifferentiated …
A story in the Milwaukee Journal Sentinel reflects on the history of stem cells and its future direction. Two decades after the first stem cell breakthrough, the promising biological discovery is beginning to take steps toward clinical trials. Waisman Center investigator David Gamm, who researches stem cell therapies for diseases of the eye, reflects on …
In a study published today, Waisman Center investigators Su-Chun Zhang, Albee Messing and colleagues point to new understandings of the broad range of effects that result from the GFAP mutation impacting astrocytes — important supporting cells which comprise 20 to 40 percent of all cells in the brain. Cells donated by patients with Alexander disease …
Waisman Center investigator David Gamm, MD, PhD, and affiliate Krishanu Saha, PhD, are part of a team of scientists at the University of Wisconsin- Madison who were recently granted a major award from the National Institute of Health’s Somatic Cell Genome Editing Consortium (SCGE). This award will support research focused on developing quality control methods …
In 1998, UW–Madison developmental biologist James Thomson introduced the world to the first laboratory-derived human embryonic stem cells. Twenty years later, UW–Madison remains at the forefront of stem cell research. The Waisman Center at UW–Madison is a hub of stem cell research, especially in the fields of human development, developmental disabilities and neurodegerative disorders. You …
Research by Waisman affiliate Jon Audhya shows new insight into the molecular basis underlying the neurodegenerative condition, hereditary spastic paraplegia (HPS). His recent study shows how a mutation in the TFG gene–one of several linked to HPS–impairs neurons from forming structures needed to transmit signals properly. Read the full article, please visit https://www.med.wisc.edu/news-and-events/2018/september/nerve-cell-protein-factory/
