Many people with single-sided deafness have tinnitus in the deaf ear (and normal hearing in the other ear). We are conducting a clinical trial in collaboration with surgeons at Harvard Medical School, to determine if a CI in the deaf ear provides: (A) relief from tinnitus due to the electrical stimulation, and (B) improved ability to localize sounds.
Slide of the Week
James Li, PhD – Slide of the Week
Inconsistent parental discipline is a robust correlate of child attention-deficit/hyperactivity disorder (ADHD) symptoms, but few studies have considered the role of inconsistent positive parenting on ADHD, as well as the effects of stress on negative and positive parental consistency.
Margarita Kaushanskaya, PhD – Slide of the Week
This study tested the effect of Spanish-accented speech on sentence comprehension in children with different degrees of Spanish experience. The hypothesis was that earlier acquisition of Spanish would be associated with enhanced comprehension of Spanish-accented speech.
Katherine C. Hustad, PhD – Slide of the Week
Although children with cerebral palsy (CP) are at an increased risk for developing speech, language, and executive function (EF) impairments, little is known regarding the relationship among these risk factors.
Edward Hubbard, PhD – Slide of the Week
One of the key ways that we make sense of numbers is by creating a “mental number line”. Previous research with whole numbers has demonstrated that (at least in Western cultures) small numbers are thought of as being on the left side of space, and large numbers on the right.
Sigan Hartley, PhD – Slide of the Week
We compared the couple conflict of parents of children with autism spectrum disorder (ASD) to a comparison group of parents of children without disabilities using self-reported and observational measures.
H. Hill Goldsmith, PhD – Slide of the Week
Using Discordant MZ Twins and Genome-wide Methylation Analyses to Identify Anxiety-relevant Genes – Three MZ (genetically identical) twin pairs were chosen to be clearly discordant for childhood cortisol levels and adolescent fMRI patterns in the amygdala that correlated with anxiety symptoms.
Anita Bhattacharyya, PhD – Slide of the Week
Generation of Human Induced Pluripotent Stem Cells from Unaffected Neonatal Skin Cells – We have generated and characterized iPSC clones from three unaffected, neonatal individuals using non-integrating episomal reprogramming plasmids expressing OCT4, SOX2, LIN28, KLF4, and c-Myc.
David Gamm, MD, PhD
Cell type-specific investigations commonly employ gene reporters or single-cell (sc) analytical techniques. However, reporter line development is arduous and generally limited to a single gene of interest, while scRNA-seq frequently yields equivocal results that preclude definitive cell identification.
Peter Ferrazzano, MD
Immunostaining and microglia isolation via magnetic cell sorting was performed at postnatal day 2, 9, 30 and 60 (P2, P9, P30, P60). Microglia branching and soma size were quantified using semiautomated software analysis (Imaris, Oxford Insturments).