Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
A new review paper published in Nature Reviews Neuroscience from Bhattacharyya, associate professor of cell and regenerative biology, pulls together what is currently known about DS’s impact on brain development.
The appearance of cognitive deficits in infancy suggests that alterations emerge during the earliest stages of neural development and continue throughout the lifespan in DS.
Title: Single-cell gene expression analysis reveals signatures of adult neurogenesis in mouse, pig and macaque, but not in humans. Legend: A) Schematic of the analytic workflow. DG: dentate gyrus; CA: cornu ammonis; Sub: subiculum; EC: entorhinal cortex B) Seurat integration of all cells in the dentate gyrus (each dot represents one cell). RGL: radial glia-like cell; …
Research has shown voluntary running is an activity most commonly associated with the reversal of negative impacts of aging and neurodegeneration, but little is understood about why that is.
In one of the first studies to “read” the genetic activity inside individual brain cells, University of Wisconsin—Madison neuroscientist Xinyu Zhao has identified the genetic machinery that causes maturation in a young nerve cell.
