Alzheimer’s disease is characterized by accumulation of beta amyloid (Aβ) and hyperphosphorylated tau proteins, which neuropathology suggests follow distinct spatiotemporal patterns.
Slide of the Week
Qiang Chang, PhD
Rett syndrome (RTT) is a debilitating neurodevelopmental disorder caused by mutations in the MECP2 gene. To facilitate the study of cellular mechanisms in human cells, we established several human stem cell lines.
Pelin Cengiz, MD
Astrogliosis following hypoxia-ischemia (HI) related brain injury plays a role in increased morbidity and mortality in neonates. Recent clinical studies indicate that the severity of brain injury appears to be sex-dependent and that male neonates are more susceptible to the effects of HI resulting in worse neurological outcomes compared to females with comparable brain injuries.
Murray Brilliant, PhD
Height is a highly heritable, classic polygenic trait with approximately 700 commonly associated variants identified through genome-wide association studies so far.
Karla Ausderau, PhD
Objective – Identify and describe parents’ strategies used to support mealtime participation for their child with autism spectrum disorder (ASD).
Andrew Alexander, PhD
Mapping White Matter Microstructure in the One Month Human Brain Legend: Matched coronal and axial slices through the of the population averaged diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) parameters …
Luigi Puglielli, MD, PhD
Increased expression of AT-1/SLC33A1 causes an autistic-like phenotype in mice by affecting dendritic branching and spine formation Legend: AT-1 Tg animals display changes in neuronal morphology and imbalanced synaptic plasticity. (A-D) Morphological assessment of hippocampal neurons …
Xinyu Zhao, PhD
Integrative Single-Cell Transcriptomics Reveal Molecular Networks Defining Neuronal Maturation during Postnatal Neurogenesis Legend: Left: An illustration of coronal section of Nissl-stained adult mouse brain; Confocal images showing that most of DsRed+ (red) cells in DCX-dsRed …
Su-Chun Zhang, MD, PhD
Alexander disease patient astrocytes have impaired calcium wave propagation Legend: A) Still images over time from mechanical stimulation of 6-month astrocytes loaded with Fluor-4AM and accompanying post-experiment GFAP stains. B) Average duration of increased calcium …
Houri Vorperian, PhD
We present a registration-based semi-automatic mandible segmentation (SAMS) pipeline designed to process a large number of computed tomography studies to segment three dimensional (3D) mandibles.