Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
James Li’s drive to research, understand and develop effective interventions for childhood behavioral disorders, such as attention deficit hyperactivity disorder (ADHD), was sparked in the hallways of a juvenile justice center in Baltimore.
Title: Perceptual Ratio Processing Predicts Fractions Skills Legend: (Lay): College students were asked to decide which of two ratios were larger (examples in a-d) that were presented for 1.5 seconds. We show that people who were better at this perceptual task also performed better on four tasks involving symbolic fractions: comparing symbolic fractions (e.g., saying …
Title: iPSC derived Optic Vesicles (OVs)/Neural Retinal Progenitors (NRPs) – Production, Characterization and Cryopreservation Legend: 1) Representative pictures of selected OVs derived from iPSCs grown on E8/Matrigel. iPSCs, cultured on E8/Matrigel, mTeSR1/Matrigel, and E8/vitronectin, were differentiated into OVs (Optic vesicle-like structures) composed of NRPCs (neuroretinal progenitor cells). 2) Characterization of OVs (60 days in culture)- …
Couples raising a child with developmental disabilities do not face a higher risk of divorce if they have larger families, according to a new study by researchers from the Waisman Center at the University of Wisconsin-Madison.
Title: Support Needs of Fathers and Mothers of Children and Adolescents with Autism Spectrum Disorder Legend: Left, top image: The most support needs most frequently rated as both important and unmet for both mothers and fathers. Mothers’ non-overlapping top important, unmet support needs were child-focused (financial support for treatments, information about programs and services, and …
Anyone paying attention to these editorials knows we are passionate supporters of the Waisman Center, especially of the life-changing research into neurodegenerative diseases and causes of developmental disabilities done there.
Many expected the Human Genome Project to cause a revolution far beyond the field of genetics — into economics and culture — and thought the 13-year, $3 billion international research endeavor would allow us to understand and control viruses, identify the root causes of cancers, advance forensics, create better crops and update anthropology tools to get a better view of our evolutionary path.
Title: Characterization of a unique cell population marked by transgene expression in the adult cochlea of nestin-CreER(T2)/tdTomato-reporter mice Legend: Left image: Cochlea from an adult nestin-CreERT2/tdTomato-reporter mouse 56 days post tamoxifen injection. Low power macroscopic imaging analysis showed a pattern of tdTomato expression on the neural aspect of Sox2-positive supporting cells. An apical-basal gradient was not …
Title: The Relative Divorce Risk in Parents of a Child with Developmental Disabilities Legend: Left image: The Kaplan-Meier survival analysis with parents of a child with developmental disabilities (n=190) compared to parents of children without any disabilities (n=7,251) revealed that the two groups of parents do not show significantly different survival (i.e., remaining married) functions across …
Women who have a child with fragile X syndrome (FXS) and are themselves carriers of a “premutation” in the gene linked to FXS are at an increased risk of developing depression and certain kinds of anxiety disorders over time, according to a recent study by researchers at the Waisman Center and the University of South Carolina.
