Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Title: Presence, Proximity, and Peer Interactions of Adolescents with Severe Disabilities in General Education Classrooms Legend: Percentage of students with severe disabilities who are present in the general education classroom and in proximity to peers without severe disabilities by percentage of elapsed time in the class period. Citation: Feldman, R.L., Carter, E.W., Brock, M.E., & …
Title: Sensory Subtypes and Associated Outcomes in Children with Autism Spectrum Disorders Legend: Vineland Adaptive Behavior Scale 2nd Edition- adaptive behavior composite score, domains, and maladaptive score by sensory subtype (Mild Subtype, Sensitive-Distressed Subtype, Attenuated-Preoccupied Subtype, and Extreme-Mixed Subtype). Parenting Stress Index 3rd Edition, Short Form- total score, parental distress, difficult child, and parent/child dysfunctional …
Title: Investigating the Microstructural Correlation of White Matter in Autism Spectrum Disorder Legend: Graphical visualization (‘connectogram’) of brain white matter networks of the examined typically developing (TD) and autism spectrum disorder (ASD) groups. Individual white matter tracts were broadly grouped by region (outside labels), while the individual tract is indicated by the inside of the …
Title: MDM2 inhibition rescues neurogenic and cognitive deficits in a mouse model of fragile X syndrome Legend: Left: Models for FMRP regulation of the MDM2 and P53 pathway, which impacts adult neurogenesis and cognition. Right upper: Schematic of novel location test for assessing spatial learning. Right lower panel Nutlin-3 treatment fully rescued spatial memory deficits in Fmr1 …
Title: Glycomacropeptide (GMP) is a bioactive peptide released from casein in milk during cheesemaking that contains no aromatic amino acids. GMP is isolated for use in medical foods for the management of phenylketonuria (PKU) based on research conducted in Dr. Denise Ney’s laboratory at UW–Madison. GMP is an acidic, highly polar peptide that is hydrophilic …
Title: Hyoid bone fusion and bone density across the lifespan: prediction of age and sex Legend: Hyoid bone fusion rank definition (left panel) with images showing the same fusion rank bilaterally. The 3D Hyoid bone models (middle panel) were created using image visualization and analysis software Analyze 11.0 (AnalyzeDirect; Overland Park, KS). The CT scan …
Title: Longitudinal development of grip strength in individuals with Autism Spectrum Disorder (ASD) Legend: The group with ASD demonstrated atypical motor development, characterized by similar grip strength during childhood but increasingly weaker grip strength from adolescence into adulthood. Grip strength was associated with adaptive daily living skills both concurrently and 8 years into the future, suggesting that …
Title: Appliance displays: accessibility challenges and proposed solutions Legend: Sample LED display containing a string of digits, each of which is a standard seven-segment digit. For each digit, our algorithm estimates its bounding box (shown in white) and then reads it aloud using text-to-speech (results in yellow). Citation: Fusco, G., Tekin, E., Giudice, N. A., …
Title: The Sox10 transcriptional regulator binds genes important for myelin formation in both oligodendrocytes of the spinal cord and Schwann cells in peripheral nerves. Legend: The diagram shows data from next generation sequencing techniques (known as ChIP-seq) to identify elements of DNA controlled by Sox10, which is required for formation of myelin in the central …
Title: Skeletal muscle cells derived from human pluripotent stem cells Legend: Suzuki lab recently initiated a new project to establish skeletal muscle progenitor/stem cells derived from human pluripotent sources. Our culture method can produce skeletal muscle progenitor cells from human pluripotent stem cells generated from both healthy donors and patients with neuromuscular disorders. Such differentiated …
