Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
The endoplasmic reticulum acetylation machinery has emerged as a new branch of the larger endoplasmic reticulum quality control system.
The endoplasmic reticulum acetylation machinery has emerged as a new branch of the larger endoplasmic reticulum quality control system.
Cells make a lot of trash. Probably more than you’d think. So, cells have a trash disposal system that efficiently cleans up and recycles any waste that is produced. But when there are issues with the disposal system and trash builds up in the cell, that can lead to disease. This has led researchers to consider the trash disposal system as a target for potential disease treatments and therapies.
N ε-lysine acetylation within the lumen of the endoplasmic reticulum is a recently characterized protein quality control system that positively selects properly folded glycoproteins in the early secretory pathway.
A new study from the lab of UW-Madison professor of medicine Luigi Puglielli, MD, PhD, opens a door to potential treatments for diseases of age, such as Alzheimer’s disease, by defining the roles of two enzymes that are imperative to protein production.
