Our goal was to define the genetic cause of the profound hypomyelination in the taiep rat model and determine its relevance to human white matter disease.
John Svaren
Proposals by Waisman investigators selected for UW-Madison Cluster Hire Initiative
Several Waisman Center investigators played key roles in crafting research proposals that were recently selected as ‘cluster hires’ by the University of Wisconsin-Madison. UW–Madison’s Cluster Hiring Initiative was launched in 1998 as an innovative partnership …
John Svaren, PhD
Peripheral nerve regeneration after injury is dependent upon implementation of a novel genetic program in Schwann cells that supports axonal survival and regeneration.
Better understanding a devastating neurological disease
Waisman Center investigator John Svaren collaborated with Ian Duncan, a professor of veterinary medicine at the University of Wisconsin–Madison, and others on a study that offers new insight into a rare human disease, called H-ABC, …
A case of (peripheral) nerves
Every day, Waisman Center researcher John Svaren deals with nerves – peripheral nerves, that is. Peripheral nerves connect the brain and spinal cord to our limbs and organs, serving as vital communication relays that allow …
John Svaren, PhD
Title: The Sox10 transcriptional regulator binds genes important for myelin formation in both oligodendrocytes of the spinal cord and Schwann cells in peripheral nerves. Legend: The diagram shows data from next generation sequencing techniques (known …
Genome editing takes research one step closer to a cure for Charcot-Marie-Tooth disease
John Svaren, PhD’s paper “Genome editing-enabled HTS assays expand drug target pathways for Charcot-Marie-Tooth disease,” examines how the use of genome editing places his research one step closer to a potential cure for Charcot-Marie-Tooth disease.
Researchers Discover Gene Crucial For Nerve Cell Insulation
Researchers funded by the National Institutes of Health have discovered how a defect in a single master gene disrupts the process by which several genes interact to create myelin, a fatty coating that covers nerve cells and increases the speed and reliability of their electrical signals.