Trisomy 21 (Down syndrome; DS) leads to an overproduction of amyloid precursor protein and an increased risk for early Alzheimer’s disease. A study of the natural history of AD-related neuropathology is ongoing to gain an understanding of the distribution and time course of b-amyloid and tau burden in the brains of adults with DS.
Slide of the Week
Murray Brilliant, PhD – Slide of the Week
Defining the full spectrum of human disease associated with a biomarker is necessary to advance the biomarker into clinical practice. We hypothesize that associating biomarker measurements with EHR populations based on shared genetic architectures would establish the clinical epidemiology of the biomarker.
Sriram Boothalingam, PhD – Slide of the Week
The auditory efferent system (ES) originates in the auditory cortex and terminates in the cochlea (inner ear). The activity of the ES has several hypothesized implications for human hearing: facilitating speech understanding in noisy environments, protecting the sensitive inner ear against loud noise, and serving as biological markers of damage in the auditory system.
Anita Bhattacharyya, PhD – Slide of the Week
Neuropathology of the Down syndrome cerebral cortex includes fewer interneurons in upper cortical layers.
Barbara B. Bendlin, PhD – Slide of the Week
To test the hypothesis that cognitively unimpaired individuals with Alzheimer disease (AD) neuropathology differ from individuals with AD dementia on biomarkers of neurodegeneration, synaptic dysfunction, and glial activation.
Andrew Alexander, PhD – Slide of the Week
Title: Associations of prenatal maternal depression and anxiety symptoms with infant white matter microstructure Legend: Decreased frontal neurite density in the prefrontal white matter (blue highlighted regions) of 1-month old infants was associated with higher prenatal …
Ben Parrell, PhD – Slide of the Week
When we speak, we are able to use what we hear about that speech (auditory feedback) to alter our speech movements both in real time within a single word (feedback control) as well as over longer time scales across multiple utterances (feedforward control).
Caroline A Niziolek, PhD – Slide of the Week
Disorders of speech production may be accompanied by abnormal processing of speech sensory feedback. Here, we introduce a semi-automated analysis designed to assess the degree to which speakers use natural online feedback to decrease acoustic variability in spoken words.
Xinyu Zhao, PhD – Slide of the Week
Adult neural stem cells in mouse models of fragile X syndrome (FXS) have elevated histone acetylation, leading to reduced neurogenesis. Treatment with either Nutlin-3 or Curcumin rebalances histone acetylation and rescues cognitive functions
Houri K. Vorperian, PhD – Slide of the Week
A single-word identification test was used to study speech production in children and adults with Down syndrome (DS) to determine the developmental pattern of speech intelligibility with an emphasis on vowels.