Neighborhood disadvantage is associated with differences in early brain development

The study highlights associations between neighborhood disadvantage and an MRI measure of myelin maturation, a marker of brain development, across infancy and childhood.

RNA-binding protein identified as key regulator of brain development

A new Waisman Center, University of Wisconsin-Madison study has identified a critical regulator of this early process of cell fate called FXR1, a protein that binds RNA to regulate the abundance of key genes.

Xinyu Zhao, PhD – Slide of the Week

The human genome has many short tandem repeats, yet the normal functions of these repeats are unclear.

First drug to treat Alexander disease approved by the FDA after three decades of research at UW–Madison

Waisman Center launches program for autistic adults, targeting care gap after childhood

From The Daily Cardinal

New drug shows promise for treating Down syndrome-related brain changes

Individuals with Down syndrome have differences in how their brains form that cause intellectual disability. Down syndrome or trisomy 21 is the most common genetic cause of intellectual and developmental disability and is caused by the triplication of chromosome 21.

Waisman investigators receive NIH funding to optimize the use of brain organoids in research

A newly funded project will combine the expertise of four Waisman Center investigators to develop advanced machine learning methods for studying brain organoids, three-dimensional cell clusters grown from stem cells that closely mimic key aspects of human brain development.

Daifeng Wang, PhD – Slide of the Week

Spatial sequencing technologies enable the single-cell-level study of molecular organization in tissues.

Lawrence University senior takes on language development research at Waisman

Giang Pham, a rising senior from Lawrence University in Appleton, is spending her second summer doing research at the Waisman Center University of Wisconsin–Madison as part of an internship program established and supported by the late John Mielke, MD, a former member of the Waisman Board of Visitors and Appleton native, and his wife Sally. …

Puerto Rico to become a site for The Alzheimer Biomarker Consortium – Down syndrome

Puerto Rican families have started traveling to Wisconsin to be part of the research study, but the goal is to build the infrastructure to eventually conduct the studies on the island.