Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Legend: Top: A-B. 3D rendering of structured illumination microscopy (SIM) images of a human forebrain neuron growth cone triple-labeled for F-actin (red), ßIII tubulin (blue) and ADAM17 (green). A view of the apical surface (A) shows an F-actin foci in the central domain (arrowhead), which is revealed to be an apically directed protrusion in a lateral …
Legend: Left image: Children chronically at-risk for sensory processing disorders are more likely to have lower birthweight, lower gestational age, less sootheable and more fearful temperaments as toddlers. Right image: Severity of Age 4 sensory related behaviors (tactile sensitivity, auditory sensitivity, and movement) vary by risk for sensory processing disorders assessed at ages 2 and 7 …
Title: Pharmacological modulation of photoreceptor outer segment degradation in Best disease patient-derived hiPSC-RPE Legend: (a) Representative western blot analysis comparing the amount of the POS protein RHO in untreated and VPA-treated (500 µmol/l) BD hiPSC-RPE at 0 and 24 hours after POS feeding. (b) Quantification of RHO levels 24 hours after POS feeding in untreated versus …
Title: Suppression of microglia activation after hypoxia-ischemia results in age-dependent improvements in neurologic injury. Legend: P9 and P30 mice were exposed to unilateral hypoxia-ischemia and treated with minocycline or vehicle. A, B. Double immunohistological staining for Iba1 (green) and MAP2 (red) proteins in the CA1 region of the hippocampus at 2 days post-HI is shown. …
Legend: Latent growth curve modeling of longitudinal data (age 2-5 years) for 129 young children with ASD revealed four severity trajectory classes based on calibrated severity scores from the Autism Diagnostic Observation Schedule (ADOS): Persistent High (n=47); Persistent Moderate (n=54), Worsening (n=10), and Improving (n=18). The dashed line indicates the mean trajectory within each class. …
Legend: Fig. 1. The tokens of the determiner the for the three item types. Note the canonical formant transitions for the facilitating tokens and the steady formant values in the neutral token. Fig. 2. Proportion looking to target from onset of the to 1250 ms after target-word onset in the two conditions. Symbols and error bars …
Citation: Inter-pregnancy intervals and the risk of autism spectrum disorder: results of a population-based study. Durkin MS, DuBois LA, Maenner MJ, Journal of Autism and Developmental Disorders, 2015; 45(7): 2056-66. Abstract: Recent studies have reported an increased risk of autism among second-born children conceived <12 months versus >36 months after the birth of a sibling. …
Title: Amygdala and hippocampal volume is reduced in children exposed to different forms of adversity Legend: Volumetric comparisons for the left amygdala (A) and left (B) and right (C) hippocampus. For each graph, standardized residuals controlling for total gray matter, pubertal stage, and sex are shown on the vertical axis, and group is shown on the …
Title: Tai Chi as a potential therapy for ADHD Legend: Healthy young adults in a tai chi course reported reduced levels of inattention compared to controls. Photo: © Mariann Seriff (https://nccih.nih.gov/news/multimedia/images/details/2862) Citation: Converse AK, Ahlers EO, Travers BG, Davidson RJ (2014) Tai chi training reduces self-report of inattention in healthy young adults. Frontiers in Human …
Legend: Left panel: General patterns of [11C]PiB binding in participants with Down syndrome (DS). PiB binds to amyloid-β plaques, a neuropathological hallmark of Alzheimer’s disease (AD). The top row shows nonspecific white matter binding. The middle row shows elevated PiB binding only in the striatum (pointed out by the arrows), which is unique to the …
