A new machine learning algorithm developed at UW-Madison is helping researchers untangle a complex puzzle: the molecular mechanisms behind developmental disabilities and neurodegenerative diseases. COSIME, created by the lab of Waisman investigator Daifeng Wang, PhD, associate professor of biostatistics and medical informatics, and computer sciences, offers a powerful new way to integrate and interpret multiple types of biological data which can give scientists a clearer view of how different cellular clues come together to shape disease outcomes.
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New research reinforces the link between a cellular quality control system and rare forms of autism
Just like a car factory relies on inspectors to ensure that every vehicle is built correctly, cells depend on internal quality control systems to keep proteins functioning as they should. New research from Waisman Center investigator Luigi Puglielli, MD, PhD, professor of medicine at the University of Wisconsin-Madison, reveals that disruptions in one such system—the endoplasmic reticulum’s acetylation pathway—can lead to rare forms of autism and progeria, offering fresh insights into the cellular roots of these complex conditions.
A tribute to Paul White: Champion of community, compassion, and change
Paul White, MA, founder of Community TIES and former director of the Waisman Center’s Community Outreach Wisconsin program, passed away unexpectedly on June 17, 2025.
New research suggests mixing languages during study session might be a more effective learning method
A new paper from the lab of Waisman investigator Margarita Kaushanskaya, PhD, professor of communication sciences and disorders at UW-Madison, provides evidence that suggests when trying to learn two languages, studying them both during the same session rather than separately might be the more beneficial strategy.
Lily Wagner on researching, diagnosing and treating autism
Waisman Center Autism and Developmental Disabilities Clinic Director Lily Wagner considers the Trump administration’s warnings about acetaminophen and approval of leucovorin as a treatment for autism. By Frederica Freyberg | Here & Now September 26, …
Wisconsin researcher responds to White House autism announcement
Since that press conference on Monday afternoon, numerous medical organizations have pushed back, saying acetaminophen is safe for pregnant women to use
As Trump warns of danger with acetaminophen, autism community calls for support, not cure
Natalie Eilbert Milwaukee Journal Sentinel At 40, Erin Miller takes solace in the ordinary joys of life. She goes on nature walks, watches the seasonal butterflies, enjoys a good bowl of ice cream, and plays …
Undergraduate student research experience is an integral part of the Zhao lab
By Anoushka Kar The Zhao lab at the University of Wisconsin–Madison is an exciting and dedicated research entity in neuroscience which focuses on brain development and developmental disorders. It offers opportunities to students of any …
New study shows nuanced and complex relationship between tau and brain cell loss in Alzheimer’s Disease
At a Glance Loss of synapses, the connections between neurons that allow them to communicate, is a primary driver of cognitive decline in Alzheimer’s disease. Researchers expected a strong connection between synapse loss and tau …
Integrating trauma awareness into early language support
Learning language in early childhood occurs through interaction between children and their caregivers. It is a foundational process that allows children to participate in social interactions, learn from the world, and develop other essential skills such as literacy. Having a language delay or disorder is associated with greater risk for experiencing trauma and vice versa. Furthermore, children’s and caregivers’ trauma histories can impact their individual strengths and needs related to participation in early language intervention.