Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
At a Glance: A map of early brain development that captures its major drivers and their dynamics through time has been developed by Waisman Center investigators. Compiling different brain regions across three different species including humans, the new blueprint can identify the upstream regulators of brain development, evolution, and disorder risk, revealing how highly complex …
The study highlights associations between neighborhood disadvantage and an MRI measure of myelin maturation, a marker of brain development, across infancy and childhood.
A new Waisman Center, University of Wisconsin-Madison study has identified a critical regulator of this early process of cell fate called FXR1, a protein that binds RNA to regulate the abundance of key genes.
Just like a car factory relies on inspectors to ensure that every vehicle is built correctly, cells depend on internal quality control systems to keep proteins functioning as they should. New research from Waisman Center investigator Luigi Puglielli, MD, PhD, professor of medicine at the University of Wisconsin-Madison, reveals that disruptions in one such system—the endoplasmic reticulum’s acetylation pathway—can lead to rare forms of autism and progeria, offering fresh insights into the cellular roots of these complex conditions.
Evidence-based assessment pathways inform early detection of cerebral palsy and access to intervention.
By Emily Leclerc, Waisman Science Writer The Waisman Center welcomes a new affiliated investigator Justin Wolter, PhD, assistant professor of medical genetics. Wolter comes to Waisman and UW–Madison from the University of North Carolina at Chapel Hill (UNC), where he completed his postdoctoral fellowship. “The scientific and intellectual environment at UW is just amazing,” Wolter …
