Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Individuals with Down syndrome (DS) are at increased risk of developing Alzheimer’s disease (AD) and show the earliest signs of amyloid-β (Aβ) deposition in the striatum. The metric for tracking Aβ burden using PET radiotracers frequently uses average standard uptake value ratios (SUVr) in signature regions of the brain specific to Aβ deposition.
Leann Smith DaWalt, PhD, a longtime Waisman Center investigator, began her appointment as the director of the University Center for Excellence in Developmental Disabilities (UCEDD) on Oct. 14. She succeeds Bill MacLean, PhD, who retired in early October. The UCEDD supports the full inclusion and self-determination of people with developmental disabilities and their families through …
If you ask David Seamans what his favorite thing to do is, he’ll pause thoughtfully for a moment before responding, “Everything.” He really does mean everything
The auditory brainstem reflex tag-team: panel A is a schematic of the neural connections between two brainstem auditory reflexes, the medial olivocochlear (MOCR) and the middle ear muscle (MEMR) reflex. While we know that the two reflexes work in tandem and at slightly different frequencies and input sound levels, how the activity of one reflex influences the other is poorly understood.
There is no car in the driveway, neither phone nor electricity in the house. Handmade clothes dry on the line. It’s fall 2018, and La Farge physician James DeLine has brought us to talk with Barbara and Daniel Hochstetler, part of the large Amish population in Wisconsin’s Driftless Region.
To identify mechanisms that lead to neurodevelopmental differences in Down syndrome, we used induced pluripotent stem cells (iPSCs) generated from individuals with Down syndrome and differentiated them into progenitors of the cerebral cortex. The progenitors were analyzed by RNA Seq at Day 17 in culture when cells have acquired their positional phenotype.
WAISMAN WHIRL Madison, WI 10/06/2019 ********** OVERALL 5K RUN RESULTS ********** Place Bib Name Sex City Div/Tot Div Finish Pace ===== ===== ======================= === ================ ======== ========== ======= ===== 1 2510 Kyle Fisher M 1/4 M11-19 25:41 8:16 2 2505 Nick Burkee M 1/7 M30-39 26:18 8:28 3 2507 Payton Cigler F 1/1 F11-19 26:23 …
The Waisman Center is one of 25 recipients to receive funding through a National Institutes of Health (NIH) grant that focuses on advancing research on Down syndrome. The grant is part of the NIH Investigation of Co-occurring Conditions Across the Lifespan to Understand Down Syndrome (INCLUDE) project. INCLUDE is a trans-NIH effort that will fund …
Trimethylamine N-oxide (TMAO), a small molecule produced by the metaorganismal metabolism of dietary choline, has been implicated in human disease pathogenesis, including known risk factors for Alzheimer's disease (AD), such as metabolic, cardiovascular, and cerebrovascular disease.
After 27 years as the director of the Waisman Early Childhood Program (WECP), Joan Ershler, PhD, retired in early September 2019. The WECP is a model inclusive early childhood program with a developmentally diverse enrollment serving children with special needs alongside their typically developing peers. Under her leadership, the program grew substantially. The number of children …
