Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Alzheimer’s disease is characterized by accumulation of beta amyloid (Aβ) and hyperphosphorylated tau proteins, which neuropathology suggests follow distinct spatiotemporal patterns.
Rett syndrome (RTT) is a debilitating neurodevelopmental disorder caused by mutations in the MECP2 gene. To facilitate the study of cellular mechanisms in human cells, we established several human stem cell lines.
Children living in neighborhoods where incomes are low and fewer adults have bachelor’s degrees are less likely to be diagnosed with autism spectrum disorder compared to kids from more affluent neighborhoods. The finding is part of a new multi-institution study of autism spectrum disorder (ASD), led by Maureen Durkin of the University of Wisconsin–Madison’s Waisman …
A recent story in the New York Times discusses the trauma that parents experience after the death of a child. In particular, elderly parents who lose a child are vulnerable both emotionally and pragmatically. Waisman Center investigators Marsha Mailick, PhD, and Jan Greenberg, PhD, are quoted in the article and their research is highlighted. You …
Astrogliosis following hypoxia-ischemia (HI) related brain injury plays a role in increased morbidity and mortality in neonates. Recent clinical studies indicate that the severity of brain injury appears to be sex-dependent and that male neonates are more susceptible to the effects of HI resulting in worse neurological outcomes compared to females with comparable brain injuries.
Height is a highly heritable, classic polygenic trait with approximately 700 commonly associated variants identified through genome-wide association studies so far.
Myelin and myelin-producing oligodendrocytes appear to be affected in Alzheimer’s disease (AD), but this is understudied in humans, particularly in the early stages of disease development.
Objective – Identify and describe parents’ strategies used to support mealtime participation for their child with autism spectrum disorder (ASD).
Waisman Biomanufacturing and Waisman affiliate investigators Randolph Ashton and Krishanu Saha will be part of a new engineering research center that will develop transformative tools and technologies for the consistent, scalable and low-cost production of high-quality living therapeutic cells. Such cells could be used in a broad range of life-saving medical therapies now emerging from …
Mapping White Matter Microstructure in the One Month Human Brain Legend: Matched coronal and axial slices through the of the population averaged diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) parameters (Left). Gestation corrected age relationships of fractional anisotropy (FA), radial diffusivity (RD) and neurite density (νIC) for left hemisphere white …
