Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
A Q&A with new Waisman Center investigator Lauren Bishop-Fitzpatrick. How did you get into your field of research? Like many people who pursue social work degrees, I always knew that I wanted to spend my career helping others. Although I first volunteered with children with autism when I was 15, it was not until I took …
As rates of autism diagnoses rise across the country, children with autism and their parents also have increasing options for therapy and treatments. The Wisconsin State Journal highlights the Waisman Center Autism Treatment Programs, and other options, for children and families with autism. To read the story, please click here.
Carl Ross has been selected to serve as managing director of Waisman Biomanufacturing. His appointment started July 1, following more than a year as its interim director. Located at the University of Wisconsin–Madison Waisman Center, the primary mission of Waisman Biomanufacturing is to help UW scientists and others efficiently translate scientific discoveries into early-stage clinical …
Increased expression of AT-1/SLC33A1 causes an autistic-like phenotype in mice by affecting dendritic branching and spine formation Legend: AT-1 Tg animals display changes in neuronal morphology and imbalanced synaptic plasticity. (A-D) Morphological assessment of hippocampal neurons in culture. Phalloidin staining (upper panels) and unbiased computer-driven reconstruction (lower panels) of both WT and AT-1 Tg neurons (A …
Integrative Single-Cell Transcriptomics Reveal Molecular Networks Defining Neuronal Maturation during Postnatal Neurogenesis Legend: Left: An illustration of coronal section of Nissl-stained adult mouse brain; Confocal images showing that most of DsRed+ (red) cells in DCX-dsRed mouse brains express immature neuron marker doublecortin (DCX, green). Middle: A schematic of the experimental design for single-cell transcriptome analysis. Right: Enrichment …
Alexander disease patient astrocytes have impaired calcium wave propagation Legend: A) Still images over time from mechanical stimulation of 6-month astrocytes loaded with Fluor-4AM and accompanying post-experiment GFAP stains. B) Average duration of increased calcium signal above threshold ± S.D. C) Average proportion of field of view traveled by calcium wave. D) Rate of calcium …
Version 26.0.0.151 of Adobe Flash Player is being rolled out to Waisman PCs today. Ask us or ask Adobe which version you are using.
We present a registration-based semi-automatic mandible segmentation (SAMS) pipeline designed to process a large number of computed tomography studies to segment three dimensional (3D) mandibles.
Waisman Center investigator Luigi Puglielli had trouble with only one class in medical school: biochemistry. Yet today he uses biochemical approaches to study some of the vital molecular mechanisms that regulate brain physiology and pathology across the lifespan. Puglielli, who is a professor in the Department of Medicine, focuses on trying to understand how proteins …
Peripheral nerve regeneration after injury is dependent upon implementation of a novel genetic program in Schwann cells that supports axonal survival and regeneration.
