TDP-43 mislocalization in a mouse model of Alexander disease Legend: Mislocalized TDP-43 colocalizes with GFAP in GfapR236H/+ mice. TDP-43 (red) and GFAP (green) immunolabeling in coronal brain sections from 10-week-old mice. Nuclei are labeled with DAPI (blue). In WT mice, TDP-43 is primarily …
Alexander disease
Tracing a path towards neuronal cell death in Alexander disease
A fruit fly model of a rare, neurodegenerative disease is helping researchers trace the series of steps that lead to neuronal cell death. Damage to astrocytes – star-shaped cells found in the brain and spinal cord – is found in many neurodegenerative conditions, but it’s been unclear exactly what role astrocyte dysfunction plays in the development of disease.
Rare disease yields clues about broader brain pathology
Alexander disease is a devastating brain disease that almost nobody has heard of — unless someone in the family is afflicted with it. Alexander disease strikes young or old, and in children destroys white matter in the front of the brain.
After 40 years, Waisman Center still at forefront of research on the brain
The telegram from President John F. Kennedy to University of Wisconsin President Fred Harrington was both eerie and visionary. Eerie because it was delivered Nov. 20, 1963 – just two days before Kennedy was assassinated in Dallas – and visionary because it seemed to anticipate the challenges confronting science in its quest to explore the human brain.
Screen yields drugs that could help treat fatal brain disorder
Using novel screens to sort through libraries of drugs already approved for use in human patients, a team of Wisconsin researchers has identified several compounds that could be used to treat a rare and deadly neurological disorder.
Spanish mother’s search leads to the Waisman Center
“Don’t give up, my love, or I’ll give up with you, because I only live to see the fulfillment of this dream: that you may continue to live. Yours is a life sentence, not a death sentence.”