Not so many years ago, people with Down syndrome rarely survived to middle age. Many died young due to heart problems associated with the congenital condition.
Today, advances in treatment have allowed them to live longer, healthier lives.
Month: October 2019
Bradley T Christian, PhD – Slide of the Week
Individuals with Down syndrome (DS) are at increased risk of developing Alzheimer’s disease (AD) and show the earliest signs of amyloid-β (Aβ) deposition in the striatum. The metric for tracking Aβ burden using PET radiotracers frequently uses average standard uptake value ratios (SUVr) in signature regions of the brain specific to Aβ deposition.
Leann Smith DaWalt, PhD, becomes UCEDD director
Leann Smith DaWalt, PhD, a longtime Waisman Center investigator, began her appointment as the director of the University Center for Excellence in Developmental Disabilities (UCEDD) on Oct. 14. She succeeds Bill MacLean, PhD, who retired …
Whole exome sequencing illuminates genetic condition
If you ask David Seamans what his favorite thing to do is, he’ll pause thoughtfully for a moment before responding, “Everything.” He really does mean everything
Sriram Boothalingam, PhD – Slide of the Week
The auditory brainstem reflex tag-team: panel A is a schematic of the neural connections between two brainstem auditory reflexes, the medial olivocochlear (MOCR) and the middle ear muscle (MEMR) reflex. While we know that the two reflexes work in tandem and at slightly different frequencies and input sound levels, how the activity of one reflex influences the other is poorly understood.
21st century medicine helps Amish deal with rare, inherited illnesses
There is no car in the driveway, neither phone nor electricity in the house. Handmade clothes dry on the line. It’s fall 2018, and La Farge physician James DeLine has brought us to talk with Barbara and Daniel Hochstetler, part of the large Amish population in Wisconsin’s Driftless Region.
Anita Bhattacharyya, PhD – Slide of the Week
To identify mechanisms that lead to neurodevelopmental differences in Down syndrome, we used induced pluripotent stem cells (iPSCs) generated from individuals with Down syndrome and differentiated them into progenitors of the cerebral cortex. The progenitors were analyzed by RNA Seq at Day 17 in culture when cells have acquired their positional phenotype.
Waisman Whirl 2019 Results
WAISMAN WHIRL Madison, WI 10/06/2019 ********** OVERALL 5K RUN RESULTS ********** Place Bib Name Sex City Div/Tot Div Finish Pace ===== ===== ======================= === ================ ======== ========== ======= ===== 1 2510 Kyle Fisher M 1/4 …
New funding for Down syndrome research and biobank
The Waisman Center is one of 25 recipients to receive funding through a National Institutes of Health (NIH) grant that focuses on advancing research on Down syndrome. The grant is part of the NIH Investigation …
Barbara B. Bendlin, PhD – Slide of the Week
Trimethylamine N-oxide (TMAO), a small molecule produced by the metaorganismal metabolism of dietary choline, has been implicated in human disease pathogenesis, including known risk factors for Alzheimer’s disease (AD), such as metabolic, cardiovascular, and cerebrovascular disease.