Alexander disease (AxD) is a devastating leukodystrophy caused by gain-of-function mutations in GFAP, and the only available treatments are supportive. Recent advances in antisense oligonucleotide (ASO) therapy have demonstrated that transcript targeting can be a successful strategy for human neurodegenerative diseases amenable to this approach.
Month: January 2022
Marsha Mailick, PhD – Slide of the Week
Title: Association between FMR1 CGG Repeat Number Polymorphism and Phenotypic Variation in the General Population Legend: Associations between CGG repeat lengths and phenotypes. (A) Linear association with IQ. (B) Linear association with college graduate (males only). (C) …
Lauren Bishop honored with Deborah K. Padgett Early Career Achievement Award
Lauren Bishop, PhD, an assistant professor in the School of Social Work and a Waisman Center investigator, was recently honored with the 2022 Deborah K. Padgett Early Career Achievement Award from the Society for Social Work and Research.
Videojuego enseña balance, reduce síntomas en adolescentes autistas
Si bien el entrenamiento de balance puede no parecer divertido para la mayoría de los adolescentes, los videojuegos generalmente sí lo son.
James Li, PhD – Slide of the Week
Title: A Gene‐Environment Interaction Study of Polygenic Scores and Maltreatment on Childhood ADHD Legend: The interaction between a categorized ADHD polygenic score (PGS) and maltreatment factor score was insignificant, although the main effects of both …
Video games teach balance, reduce symptoms in autistic adolescents
While balance training may not necessarily sound fun to most adolescents, video games typically do. And for adolescents with autism spectrum disorder, video games that improve their balance by teaching them yoga and tai chi poses also improves their posture, reduces the severity of their autism symptoms and influences the structure of their brains.
El programa SaferKids del Waisman Center brinda tranquilidad a las familias
English Por Emily Leclerc, Escritora Científica, Waisman Center Tiaunta Martin es una orgullosa madre de tres hijos. Son de ojos brillantes, enérgicos y, por lo general, un torbellino de caos. Su hijo del medio, Benjamin, …
Ruth Litovsky, PhD – Slide of the Week
Our knowledge to date about structural brain development across the lifespan in ASD comes mainly from cross-sectional studies, thereby limiting our understanding of true age effects within individuals with the disorder that can only be gained through longitudinal research.