Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Defining the full spectrum of human disease associated with a biomarker is necessary to advance the biomarker into clinical practice. We hypothesize that associating biomarker measurements with EHR populations based on shared genetic architectures would establish the clinical epidemiology of the biomarker.
Waisman Center investigator David Gamm, MD, PhD, and affiliate Krishanu Saha, PhD, are part of a team of scientists at the University of Wisconsin- Madison who were recently granted a major award from the National Institute of Health’s Somatic Cell Genome Editing Consortium (SCGE). This award will support research focused on developing quality control methods …
The auditory efferent system (ES) originates in the auditory cortex and terminates in the cochlea (inner ear). The activity of the ES has several hypothesized implications for human hearing: facilitating speech understanding in noisy environments, protecting the sensitive inner ear against loud noise, and serving as biological markers of damage in the auditory system.
As a large wave of individuals with autism spectrum disorder (ASD) diagnosed in the 1990s enters adulthood and middle age, knowledge about the patterning of lifetime health problems will become increasingly important for prevention efforts. We retrospectively analyzed diagnostic codes associated with de-identified electronic health records using a machine learning algorithm to characterize diagnostic patterns in decedents with ASD and matched decedent community controls.
Neuropathology of the Down syndrome cerebral cortex includes fewer interneurons in upper cortical layers.
To test the hypothesis that cognitively unimpaired individuals with Alzheimer disease (AD) neuropathology differ from individuals with AD dementia on biomarkers of neurodegeneration, synaptic dysfunction, and glial activation.
Title: Associations of prenatal maternal depression and anxiety symptoms with infant white matter microstructure Legend: Decreased frontal neurite density in the prefrontal white matter (blue highlighted regions) of 1-month old infants was associated with higher prenatal maternal depression and anxiety. Advanced diffusion MRI brain scans were performed on 101 infants at the Waisman Center for this …
In 1998, UW–Madison developmental biologist James Thomson introduced the world to the first laboratory-derived human embryonic stem cells. Twenty years later, UW–Madison remains at the forefront of stem cell research. The Waisman Center at UW–Madison is a hub of stem cell research, especially in the fields of human development, developmental disabilities and neurodegerative disorders. You …
Research by Waisman affiliate Jon Audhya shows new insight into the molecular basis underlying the neurodegenerative condition, hereditary spastic paraplegia (HPS). His recent study shows how a mutation in the TFG gene–one of several linked to HPS–impairs neurons from forming structures needed to transmit signals properly. Read the full article, please visit https://www.med.wisc.edu/news-and-events/2018/september/nerve-cell-protein-factory/
By Marianne Spoon, UW Communications Many factors can influence the development of a baby during pregnancy and after birth, but until recently, researchers knew little about the relationship between an expectant mother’s mental health and the subsequent development of her baby after birth. Findings from a University of Wisconsin–Madison team published Monday, Aug. 27, in …
