A new machine learning algorithm developed at UW-Madison is helping researchers untangle a complex puzzle: the molecular mechanisms behind developmental disabilities and neurodegenerative diseases. COSIME, created by the lab of Waisman investigator Daifeng Wang, PhD, associate professor of biostatistics and medical informatics, and computer sciences, offers a powerful new way to integrate and interpret multiple types of biological data which can give scientists a clearer view of how different cellular clues come together to shape disease outcomes.
Intellectual and Developmental Disabilities (IDD)
New research reinforces the link between a cellular quality control system and rare forms of autism
Just like a car factory relies on inspectors to ensure that every vehicle is built correctly, cells depend on internal quality control systems to keep proteins functioning as they should. New research from Waisman Center investigator Luigi Puglielli, MD, PhD, professor of medicine at the University of Wisconsin-Madison, reveals that disruptions in one such system—the endoplasmic reticulum’s acetylation pathway—can lead to rare forms of autism and progeria, offering fresh insights into the cellular roots of these complex conditions.
As Trump warns of danger with acetaminophen, autism community calls for support, not cure
Natalie Eilbert Milwaukee Journal Sentinel At 40, Erin Miller takes solace in the ordinary joys of life. She goes on nature walks, watches the seasonal butterflies, enjoys a good bowl of ice cream, and plays …
Meet ARTEMIS: The new AI helping researchers reconstruct the hidden stories of cell development
Building a complete developmental trajectory of cells is close to impossible with today’s technology, but new technology developed at the Waisman Center is taking scientists a step closer to achieving it. Machine learning, a form of artificial intelligence, can step in to help fill in the gaps.
Wisconsin LEND trainees visit state legislators to share their personal stories and educate about the impact of Medicaid on Wisconsinites with disabilities
The Wisconsin LEND Program prepares individuals with disabilities to engage in policy discussions, giving them the tools and confidence to make their voices heard.
Health trajectory of mothers of children with developmental disabilities shows a ‘wear-and-tear’ effect starting around age 65
Mothers of children with developmental disabilities experience long-term stress, adapting for many years but showing signs of ‘wear-and-tear’ starting around age 65, affecting their physical and mental health.
Newly funded research to study astrocyte dysfunction in Rett syndrome
The lab of Waisman Center director, Qiang Chang, PhD, professor of medical genetics and neurology, has received $1 million in funding from the Department of Defense to study the dysfunction of astrocytes, a key brain cell that supports neurons, in Rett syndrome.
CDC reports rising autism rates with Wisconsin notably higher than the national average
The prevalence of autism spectrum disorder among 8-year-old children in the U.S. has increased to 1 in 31 in 2022, up from 1 in 36 in 2020, according to a recently published report by the Centers for Disease Control and Prevention’s (CDC) Autism and Developmental Disabilities Monitoring (ADDM) Network.
Statewide success: Managing threatening confrontations training enhances disability support for thousands
It focuses on teaching proactive and positive strategies for supporting individuals with disabilities through a broad range of behaviors and escalation levels.
Change ahead: Creating a road map to help families navigate the transition to adulthood for individuals with an intellectual and developmental disability
The road to adulthood can be rough terrain. It consists of uncharted territory and many changes.